Evidence map›Paper›PMID 28040778›Full record

ArticleG3 (Bethesda, Md.)2017

Latrunculin A-Induced Perturbation of the Actin Cytoskeleton Mediates Pap1p-Dependent Induction of the Caf5p Efflux Pump in

Farzad Asadi, Bidhan Chakraborty, Jim Karagiannis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in G3 (Bethesda, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Farzad AsadiDepartment of Biology, The University of Western Ontario, London, Ontario N6A 5B7, Canada.
Bidhan ChakrabortyDepartment of Biology, The University of Western Ontario, London, Ontario N6A 5B7, Canada.
Jim KaragiannisDepartment of Biology, The University of Western Ontario, London, Ontario N6A 5B7, Canada jkaragia@uwo.ca.
Western University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As part of an earlier study aimed at uncovering gene products with roles in defending against latrunculin A (LatA)-induced cytoskeletal perturbations, we identified three members of the oxidative stress response pathway: the Pap1p AP-1-like transcription factor, the Imp1p α-importin, and the Caf5p efflux pump. In this report, we characterize the pathway further and show that Pap1p translocates from the cytoplasm to the nucleus in an Imp1p-dependent manner upon LatA treatment. Moreover, preventing this translocation, through the addition of a nuclear export signal (NES), confers the same characteristic LatA-sensitive phenotype exhibited by

Indexed as

Actin Cytoskeletonalpha KaryopherinsBasic-Leucine Zipper Transcription FactorsBridged Bicyclo Compounds, HeterocyclicCell NucleusCytoplasmGene Expression Regulation, FungalMembrane ProteinsNuclear Export SignalsOxidative StressSchizosaccharomycesSchizosaccharomyces pombe ProteinsSignal TransductionThiazolidinesalpha KaryopherinsBasic-Leucine Zipper Transcription FactorsBridged Bicyclo Compounds, HeterocyclicCaf5 protein, S pombekaryopherin alpha 2latrunculin AMembrane ProteinsNuclear Export SignalsPap1 protein, S pombeSchizosaccharomyces pombe ProteinsThiazolidinesactin cytoskeletoncell divisionfission yeastlatrunculin Astress response

Identifiers

PMID28040778
PMCPMC5295615
OpenAlexW2586427034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.