Evidence map›Paper›PMID 28040682›Full record

ReviewJournal of the National Cancer Institute2017

T-Cell Lymphoma: Recent Advances in Characterization and New Opportunities for Treatment.

Carla Casulo, Owen O'Connor, Andrei Shustov, Michelle Fanale, Jonathan W Friedberg, John P Leonard, Brad S Kahl, Richard F Little, Lauren Pinter-Brown, Ranjani Advani and 1 more

Abstract readReviewConsensus Statement
In one paragraph

Review in Journal of the National Cancer Institute, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Trial
  2. TCR Pathway Mutations in Mature T Cell Lymphomas.Journal of immunology (Baltimore, Md. : 1950) · 2023
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Challenges and implications of genomics for T-cell lymphomas.Hematology. American Society of Hematology. Education Program · 2018
    Review
  10. Review
  11. Review
  12. Article
  13. Understanding the New WHO Classification of Lymphoid Malignancies: Why It's Important and How It Will Affect Practice.American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting · 2017
    Review
  14. General Biomarker Recommendations for Lymphoma.Journal of the National Cancer Institute · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Carla CasuloWilmot Cancer Center, University of Rochester, Rochester, NY, USA.
Owen O'ConnorColumbia University Medical Center, New York, NY, USA.
Andrei ShustovSeattle Cancer Care Alliance, Seattle, WA, USA.
Michelle FanaleUniversity of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jonathan W FriedbergWilmot Cancer Center, University of Rochester, Rochester, NY, USA.
John P LeonardDepartment of Medicine, Weil Cornell University, New York, NY, USA.
Brad S KahlOncology Division, Washington University, St. Louis, MO, USA.
Richard F LittleDivision of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD, USA.
Lauren Pinter-BrownUniversity of California-Irvine Chao Family Comprehensive Cancer Center in Orange, CA, USA.
Ranjani AdvaniStanford Cancer Institute, Stanford University, Stanford, CA, USA.
Steven HorwitzMemorial Sloan-Kettering Cancer Center, New York, NY , USA.

Funding

SWOG Network Group Operations Center of the NCTNU10CA180888 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PRIMO N. LARA · 2014 to 2026
$152.1M
NCI NIH HHS U10 CA180888
6 · The paper itself

Abstract

Peripheral T-cell lymphomas (PTCLs) are uncommon, heterogeneous, and aggressive non-Hodgkin's lymphomas. Despite progress in the last several years resulting in a deeper understanding of PTCL biology and pathogenesis, there is currently no accepted single standard of care for newly diagnosed patients, and for those with relapsed or refractory disease, prognosis is dismal. The National Cancer Institute convened a Clinical Trials Planning Meeting to advance the national clinical trial agenda in lymphoma. The objective was to identify unmet needs specific to five major lymphoma subtypes and develop strategies to address them. This consensus statement reviews recent advances in the molecular and genetic characterization of PTCL that may inform novel treatments, proposes strategies to test novel therapies in the relapsed setting with the hopes of rapid advancement into frontline trials, and underscores the need for the identification and development of active and biologically rational therapies to cure PTCL at higher rates, with iterative biomarker evaluation.

Indexed as

Biomedical ResearchAnaplastic Lymphoma KinaseAurora Kinase ABiomarkersClinical Trials as TopicConsensusEndpoint DeterminationHumansJanus KinasesKi-1 AntigenLymphoma, T-Cell, PeripheralMolecular Targeted TherapyNeeds AssessmentPhosphoinositide-3 Kinase InhibitorsProto-Oncogene Proteins c-fynReceptor Protein-Tyrosine KinasesAnaplastic Lymphoma KinaseAurora Kinase ABiomarkersJanus KinasesKi-1 AntigenPhosphoinositide-3 Kinase InhibitorsProto-Oncogene Proteins c-fynReceptor Protein-Tyrosine Kinases

Identifiers

PMID28040682
PMCPMC6059211

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.