Evidence map›Paper›PMID 28040522›Full record

ReviewMatrix biology : journal of the International Society for Matrix Biology2017

The nature and biology of basement membranes.

Ambra Pozzi, Peter D Yurchenco, Renato V Iozzo

Open access · greenAbstract readReview
In one paragraph

Review in Matrix biology : journal of the International Society for Matrix Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 306 papers.

0numbers the graph read from it
0cells of the map it votes in
306citing papers in PubMed
27.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

306 citing papers in PubMed, 584 citations in OpenAlex.

  1. Article
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  9. Cell proliferation and differentiation during epidermis renewal.Journal of Zhejiang University. Science. B · 2026
    Review
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246 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Ambra PozziDepartment of Medicine, Division of Nephrology and Hypertension, Vanderbilt University, Nashville, TN, United States; Veterans Affairs Hospitals, Nashville, TN, United States. Electronic address: ambra.pozzi@vanderbilt.edu.
Peter D YurchencoDepartment of Pathology and Laboratory Medicine, Rutgers-Robert Wood Johnson Medical School, Piscataway, NJ, United States.
Renato V IozzoDepartment of Pathology, Anatomy, and Cell Biology and the Cancer Cell Biology and Signaling Program, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, United States.
Rutgers, The State University of New Jersey · USSidney Kimmel Cancer Center · USVanderbilt University · US

Funding

NEOPLASTIC MODULATION OF PROTEOGLYCAN METABOLISMR01CA039481 · NCI · UNIVERSITY OF PENNSYLVANIA · PI IOZZO, RENATO V. · 1985 to 2020
$7.1M
The Biology of Perlecan in Cancer and AngiogenesisR01CA047282 · NCI · THOMAS JEFFERSON UNIVERSITY · PI IOZZO, RENATO V. · 1990 to 2019
$5.7M
BASEMENT MEMBRANE SELF-ASSEMBLY &STRUCTURER01DK036425 · NIDDK · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI YURCHENCO, PETER DANA · 1986 to 2022
$4.3M
Basement Membrane Self-assembly and StructureR37DK036425 · NIDDK · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI YURCHENCO, PETER DANA · 2003 to 2012
$2.9M
Progranulin signaling in bladder cancerR01CA164462 · NCI · THOMAS JEFFERSON UNIVERSITY · PI IOZZO, RENATO V., MORRIONE, ANDREA · 2012 to 2016
$1.6M
Integrin/TGF-beta Axis in Tubulointerstitial FibrosisR01DK095761 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI POZZI, AMBRA · 2013 to 2016
$1.4M
Role of Collagen Binding Receptors in GlomerulosclerosisI01BX002025 · VA · VETERANS HEALTH ADMINISTRATION · PI AMBRA POZZI · 2013 to 2026
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BLRD VA I01 BX002025NCI NIH HHS R01 CA039481NCI NIH HHS R01 CA047282NCI NIH HHS R01 CA164462NIDDK NIH HHS R01 DK036425NIDDK NIH HHS R01 DK095761NIDDK NIH HHS R37 DK036425
6 · The paper itself

Abstract

Basement membranes are delicate, nanoscale and pliable sheets of extracellular matrices that often act as linings or partitions in organisms. Previously considered as passive scaffolds segregating polarized cells, such as epithelial or endothelial cells, from the underlying mesenchyme, basement membranes have now reached the center stage of biology. They play a multitude of roles from blood filtration to muscle homeostasis, from storing growth factors and cytokines to controlling angiogenesis and tumor growth, from maintaining skin integrity and neuromuscular structure to affecting adipogenesis and fibrosis. Here, we will address developmental, structural and biochemical aspects of basement membranes and discuss some of the pathogenetic mechanisms causing diseases linked to abnormal basement membranes.

Indexed as

MutationAgrinAnimalsBasement MembraneBone Diseases, DevelopmentalCollagen Type IVDiabetic NephropathiesExtracellular MatrixGene Expression RegulationHeparan Sulfate ProteoglycansHumansLamininLupus NephritisMechanotransduction, CellularMembrane GlycoproteinsProtein IsoformsAgrinCollagen Type IVHeparan Sulfate ProteoglycansLamininMembrane GlycoproteinsnidogenProtein IsoformsCollagenDiscoidin domain receptorHeparan sulfate proteoglycanIntegrinLaminin

Identifiers

PMID28040522
PMCPMC5387862
OpenAlexW2561907496

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.