ReviewJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society2017
Chest imaging in cystic fibrosis studies: What counts, and can be counted?
Review in Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- State-of-the-art review of lung imaging in cystic fibrosis with recommendations for pulmonologists and radiologists from the "iMAging managEment of cySTic fibROsis" (MAESTRO) consortium.European respiratory review : an official journal of the European Respiratory Society · 2022Pooled it
- The measurement properties of tests and tools used in cystic fibrosis studies: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2021Pooled it
- Trial
- Association Between Lung Parenchymal Attenuation in Computed Tomography and Airflow Limitation in Adults with Cystic Fibrosis.Diagnostics (Basel, Switzerland) · 2025Article
- Application of low-dose FDG-PET/MRI for quantification of lung changes in pediatric patients with cystic fibrosis: a new inflammatory index.Quantitative imaging in medicine and surgery · 2025Article
- Chest radiography and computed tomography imaging in cystic fibrosis: current challenges and new perspectives.Pediatric radiology · 2023Article
- Chest X-rays are less sensitive than multiple breath washout examinations when it comes to detecting early cystic fibrosis lung disease.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- Low- and High-Attenuation Lung Volume in Quantitative Chest CT in Children without Lung Disease.Children (Basel, Switzerland) · 2021Article
- Functional respiratory imaging in relation to classical outcome measures in cystic fibrosis: a cross-sectional study.BMC pulmonary medicine · 2021Article
- Ultra-low-dose chest CT in adult patients with cystic fibrosis using a third-generation dual-source CT scanner.La Radiologia medica · 2021Article
- Novel imaging techniques for cystic fibrosis lung disease.Pediatric pulmonology · 2021Review
- Quantification of Cystic Fibrosis Lung Disease with Radiomics-based CT Scores.Radiology. Cardiothoracic imaging · 2020Article
- Current state of the art MRI for the longitudinal assessment of cystic fibrosis.Journal of magnetic resonance imaging : JMRI · 2020Review
- [Cystic fibrosis and computed tomography of the lungs].Der Radiologe · 2020Review
- Predictive value of computed tomography scoring systems evolution in adults with cystic fibrosis.European radiology · 2020Article
- Analysis of Granulomatous Lymphocytic Interstitial Lung Disease Using Two Scoring Systems for Computed Tomography Scans-A Retrospective Cohort Study.Frontiers in immunology · 2020Article
- Current Status and Future Opportunities in Lung Precision Medicine Research with a Focus on Biomarkers. An American Thoracic Society/National Heart, Lung, and Blood Institute Research Statement.American journal of respiratory and critical care medicine · 2018Article
- Paediatric lung imaging: the times they are a-changin'.European respiratory review : an official journal of the European Respiratory Society · 2018Review
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Authors and funding
4 authors.
Funding
Abstract
backgroundThe dawn of precision medicine and CFTR modulators require more detailed assessment of lung structure in cystic fibrosis (CF) clinical studies. Various imaging markers have emerged and are measurable, but clarity is needed to identify what markers should count for clinical studies. High-resolution chest computed tomography (CT) scoring has yielded sensitive markers for the study of CF disease progression. Once completed, CT scores from ongoing randomized controlled trials can be used to examine relationships between imaging endpoints and therapeutic effectiveness. Similarly, Magnetic Resonance Imaging (MRI) is in development to generate structural as well as functional markers.
resultsThe aim of this review is to characterize the role of currently available CT and MRI markers in clinical studies, and to discuss study design, data processing and statistical challenges unique to these endpoints in CF studies. Suggestions to overcome these challenges in CF studies are included.
conclusionsTo maximize the potential of CT and MRI markers in clinical studies and advance treatment of CF disease progression, efforts should be made to conduct longitudinal randomized controlled trials including these modalities, develop data repositories, promote standardization and conduct reproducible research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.