Evidence map›Paper›PMID 28040439›Full record

ArticleJournal of theoretical biology2017

Mathematical modeling of the methionine cycle and transsulfuration pathway in individuals with autism spectrum disorder.

Troy Vargason, Daniel P Howsmon, Stepan Melnyk, S Jill James, Juergen Hahn

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of theoretical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Troy VargasonDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA.
Daniel P HowsmonDepartment of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA.
Stepan MelnykDepartment of Pediatrics, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA.
S Jill JamesDepartment of Pediatrics, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA.
Juergen HahnDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA; Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA. Electronic address: hahnj@rpi.edu.

Funding

Modeling and Analysis of the Role of Microbiota Metabolites in T-Cell DifferentiationR01AI110642 · NIAID · TEXAS ENGINEERING EXPERIMENT STATION · PI ALANIZ, ROBERT CHRISTOPHER, HAHN, JUERGEN · 2015 to 2019
$2.0M
NIAID NIH HHS R01 AI110642
6 · The paper itself

Abstract

Previous research has shown a connection between metabolic abnormalities in the methionine cycle and transsulfuration pathway and autism spectrum disorder. Using clinical data from a case-control study investigating measurements of transmethylation and transsulfuration metabolites, a steady-state model of these metabolites in liver cells was developed and participant-specific parameters were identified. Comparison of mean parameter values and parameter distributions between neurotypical study participants and those on the autism spectrum revealed significant differences for four model parameters. Sensitivity analysis identified the parameter describing the rate of glutamylcysteine synthesis, the rate-limiting step in glutathione production, to be particularly important in determining steady-state metabolite concentrations. These results may provide insight into key reactions to target for potential intervention strategies relating to autism spectrum disorder.

Indexed as

Models, TheoreticalAutism Spectrum DisorderCase-Control StudiesData Interpretation, StatisticalGlutamate-Cysteine LigaseGlutathioneHepatocytesHumansMetabolic Networks and PathwaysMethionineSulfurGlutamate-Cysteine LigaseGlutathioneMethionineSulfurParameter estimationPersonalized modelSensitivity analysisSteady-state analysisTransmethylation

Identifiers

PMID28040439
PMCPMC5293619

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.