ArticleJournal of the American Geriatrics Society2017
Outcomes of Treated Hypertension at Age 80 and Older: Cohort Analysis of 79,376 Individuals.
Article in Journal of the American Geriatrics Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Intensive versus standard blood pressure control in older persons with or without diabetes: a systematic review and meta-analysis of randomised controlled trials.Journal of the Royal Society of Medicine · 2023Pooled it
- Do we AGREE on the targets of antihypertensive drug treatment in older adults: a systematic review of guidelines on primary prevention of cardiovascular diseases.Age and ageing · 2022Pooled it
- Association between life's essential 8 and activities of daily living disability in Chinese adults aged 80 years and older: a cross-sectional study from the CLHLS.Frontiers in aging · 2026Article
- Blood pressure and adverse cardiovascular outcomes in older people with type 2 diabetes and chronic kidney disease: Findings based on the Clinical Practice Research Datalink databases in England.Diabetes, obesity & metabolism · 2026Article
- Blood Pressure and Hypertension Among Adults Aged 80 and Above: Findings From the Population-Based German Health Survey Gesundheit 65.International journal of hypertension · 2026Article
- U-shaped association between blood pressure and all-cause mortality in older adults: the Shizuoka study.Journal of human hypertension · 2025Article
- Patient survival and kidney transplantation in different dialysis modalities under PD First Policy Thailand.PloS one · 2025Article
- Systolic blood pressure, antihypertensive treatment, and cardiovascular and mortality risk in VA nursing home residents.Journal of the American Geriatrics Society · 2023Article
- Pharmacoepidemiologic study of association between apparent treatment resistant hypertension, cardiovascular disease and interaction effect by sex and age.World journal of cardiology · 2023Article
- Prognostic significance of blood pressure in frail older adults.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Blood pressure, frailty status, and all-cause mortality in elderly hypertensives; The Nambu Cohort Study.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Blood pressure in dementia, mild cognitive impairment, and subjective cognitive decline related to time of death.Brain and behavior · 2021Article
- Predictive value of attended automated office blood pressure and resting pulse rate for mortality in community-dwelling octogenarians: Minhang study.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Brazilian Guidelines of Hypertension - 2020.Arquivos brasileiros de cardiologia · 2021Article
- Blood pressure in frail older adults: associations with cardiovascular outcomes and all-cause mortality.Age and ageing · 2020Observational
- Blood Pressure Targets for Older Patients-Do Advanced Age and Frailty Really Not Matter?Canadian geriatrics journal : CGJ · 2020Article
- Perioperative Cardiac Complications in Patients Over 80 Years of Age with Coronary Artery Disease Undergoing Noncardiac Surgery: The Incidence and Risk Factors.Clinical interventions in aging · 2020Article
- Process Mining the Trauma Resuscitation Patient Cohorts.Proceedings. IEEE International Conference on Healthcare Informatics · 2018Article
- Deprescribing antihypertensive treatment in nursing home patients and the effect on blood pressure.Journal of geriatric cardiology : JGC · 2018Article
- Blood Pressure Targets in the Hypertensive Elderly.Chinese medical journal · 2017Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
objectivesTo estimate outcomes according to attained blood pressure (BP) in the oldest adults treated for hypertension in routine family practice.
designCohort analysis of primary care inpatient and death certificate data for individuals with hypertension.
settingPrimary care practices in England (Clinical Practice Research Datalink).
participantsIndividuals aged 80 and older taking antihypertensive medication and free of dementia, cancer, coronary heart disease, stroke, heart failure, and end-stage renal failure at baseline. MEASUREMENTS: Outcomes were mortality, cardiovascular events, and fragility fractures. Systolic BP (SBP) was grouped in 10-mmHg increments from less than 125 to 185 mmHg or more (reference 145-154 mmHg).
resultsMyocardial infarction hazards increased linearly with increasing SBP, and stroke hazards increased for SBP of 145 mmHg or greater, although lowest mortality was in individuals with SBP of 135 to 154 mmHg. Mortality of the 13.1% of patients with SBP less than 135 mmHg was higher than that of the reference group (Cox hazard ratio=1.25, 95% confidence interval=1.19-1.31; equating to one extra death per 12.6 participants). This difference in mortality was consistent over short- and long-term follow-up; adjusting for diastolic BP did not change the risk. Incident heart failure rates were higher in those with SBP less than 125 mmHg than in the reference group.
conclusionIn routine primary care, SBP less than 135 mmHg was associated with greater mortality in the oldest adults with hypertension and free of selected potentially confounding comorbidities. Although important confounders were accounted for, observational studies cannot exclude residual confounding. More work is needed to establish whether unplanned SBPs less than 135 mmHg in older adults with hypertension may be a useful clinical sign of poor prognosis, perhaps requiring clinical review of overall care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.