ArticlePsychiatry research. Neuroimaging2017
Impulsivity and aggression mediate regional brain responses in Borderline Personality Disorder: An fMRI study.
Article in Psychiatry research. Neuroimaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Neural correlates of aggression in personality disorders from the perspective of DSM-5 maladaptive traits: a systematic review.Translational psychiatry · 2023Pooled it
- Neural networks of aggression: ALE meta-analyses on trait and elicited aggression.Brain structure & function · 2019Pooled it
- Neural Correlates of Inhibitory Control in Impulsivity Traits in Non-Ecological Human-Computer Tasks: An ALE Meta-Analysis.Brain sciences · 2026Review
- Multi-voxel MR-spectroscopy signatures and associations with EEG network hyperexcitability and clinical symptomatology in borderline personality disorder.Frontiers in psychiatry · 2026Article
- Brain network localization of structural and functional abnormality associated with aggression.Translational psychiatry · 2025Article
- The dark sides of the brain: A systematic review and meta-analysis of functional neuroimaging studies on trait aggressionAggression and violent behavior · 2025Article
- Neuroanatomical and functional correlates in borderline personality disorder: A narrative review.Ibrain · 2025Review
- Topological Data Analysis Captures Task-Driven fMRI Profiles in Individual Participants: A Classification Pipeline Based on Persistence.Neuroinformatics · 2024Article
- Executive functions and borderline personality features in adolescents with major depressive disorder.Frontiers in human neuroscience · 2023Article
- Modeling Suicidality with Multimodal Impulsivity Characterization in Participants with Mental Health Disorder.Behavioural neurology · 2023Article
- Rethinking "aggression" and impulsivity in bipolar disorder: Risk, clinical and brain circuitry features.Journal of affective disorders · 2022Article
- Structural Features Related to Affective Instability Correctly Classify Patients With Borderline Personality Disorder. A Supervised Machine Learning Approach.Frontiers in psychiatry · 2022Article
- Psychedelic Therapy's Transdiagnostic Effects: A Research Domain Criteria (RDoC) Perspective.Frontiers in psychiatry · 2021Review
- Affective interference in borderline personality disorder: The lethality of suicidal behavior predicts functional brain profiles.Journal of affective disorders · 2019Article
- Correlates of Aggression in Personality Disorders: an Update.Current psychiatry reports · 2018Review
- Interpersonal dysfunction in borderline personality: a decision neuroscience perspective.Current opinion in psychology · 2018Review
- Impulsivity in unaffected adolescent biological relatives of schizophrenia patients.Journal of psychiatric research · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Fronto-limbic brain networks involved in regulation of impulsivity and aggression are abnormal in Borderline Personality Disorder (BPD). However, it is unclear whether, or to what extent, these personality traits actually modulate brain responses during cognitive processing. Using fMRI, we examined the effects of trait impulsivity, aggression, and depressed mood on regional brain responses in 31 female BPD and 25 control subjects during a Go No-Go task using Ekman faces as targets. First-level contrasts modeled effects of negative emotional context. Second-level regression models used trait impulsivity, aggression and depressed mood as predictor variables of regional brain activations. In BPD, trait impulsivity was positively correlated with activation in the dorsal anterior cingulate cortex, orbital frontal cortex (OFC), basal ganglia (BG), and dorsolateral prefrontal cortex, with no areas of negative correlation. In contrast, aggression was negatively correlated with activation in OFC, hippocampus, and BG, with no areas of positive correlation. Depressed mood had a generally dampening effect on activations. Effects of trait impulsivity on healthy controls differed from effects in BPD, suggesting a disorder-specific response. Negative emotional context and trait impulsivity, but not aggression or depression, diminished task performance across both groups. Negative emotional context may interfere with cognitive functioning in BPD through interaction with the neurobiology of personality traits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.