Evidence map›Paper›PMID 28039553›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2017

Deficient amygdala-prefrontal intrinsic connectivity after effortful emotion regulation in borderline personality disorder.

Blazej M Baczkowski, Linda van Zutphen, Nicolette Siep, Gitta A Jacob, Gregor Domes, Simon Maier, Andreas Sprenger, Alena Senft, Bastian Willenborg, Oliver Tüscher and 2 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Emotion Dysregulation in Personality Disorders.Current psychiatry reports · 2023
    Review
  12. Affective Neuroscience Personality Scales and Early Maladaptive Schemas in Depressive Disorders.International journal of environmental research and public health · 2022
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Current Understanding of the Neurobiology of Agitation.The western journal of emergency medicine · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Blazej M BaczkowskiDepartment of Clinical Psychological Science, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
Linda van ZutphenDepartment of Clinical Psychological Science, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands. linda.vanzutphen@maastrichtuniversity.nl.
Nicolette SiepDepartment of Clinical Psychological Science, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
Gitta A JacobDepartment of Clinical Psychology and Psychotherapy, University of Freiburg, Freiburg, Germany.
Gregor DomesDepartment of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, Freiburg, Germany.
Simon MaierFreiburg Brain Imaging Center, University Medical Center, University of Freiburg, Freiburg, Germany.
Andreas SprengerDepartments of Neurology and Psychology, University of Lübeck, Lübeck, Germany.
Alena SenftDepartment of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany.
Bastian WillenborgDepartment of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany.
Oliver TüscherDepartment of Clinical Psychology and Psychotherapy, University of Freiburg, Freiburg, Germany.
Arnoud ArntzDepartment of Clinical Psychological Science, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
Vincent van de VenDepartment of Cognitive Neuroscience, Maastricht University, Maastricht, The Netherlands.
Maastricht University · NLUniversity of Lübeck · DEUniversity of Freiburg · DEMax Planck Institute for Human Cognitive and Brain Sciences · DEUniversität Trier · DEUniversity Medical Center of the Johannes Gutenberg University Mainz · DE

Funding

and the German Research Foundation JA1785/3-1Netherlands Organization for Scientific Research (NWO) 464-10-080
6 · The paper itself

Abstract

Emotion instability in borderline personality disorder (BPD) has been associated with an impaired fronto-limbic inhibitory network. However, functional connectivity (FC) underlying altered emotion regulation in BPD has yet to be established. Here, we used resting-state fMRI to investigate enduring effects of effortful emotion regulation on the amygdala intrinsic FC in BPD. In this multicenter study, resting-state fMRI was acquired before and after an emotion regulation task in 48 BPD patients and 39 non-patient comparison individuals. The bilateral amygdalae were used as a seed in the whole-brain FC analysis and two-way mixed ANOVA to test whether BPD patients exhibited weaker post-task increase in the amygdala intrinsic FC with the prefrontal cortex (PFC), compared to non-patients. Subsequently, we explored whether the results are common for personality disorders characterized by emotional problems, using additional data of 21 cluster-C personality disorder patients. In contrast to non-patients, BPD patients failed to show increased post-task amygdala resting-state FC with the medial, dorsolateral, ventrolateral PFC, and superior temporal gyrus, but surprisingly exhibited decreased FC with the posterior cingulate cortex and increased FC with the superior parietal lobule. In BPD patients, the emotion regulation task failed to increase resting-state amygdala FC with brain regions essential for effortful emotion regulation, which suggests: (a) altered cognitive control typically used to indirectly alleviate distress by reinterpreting the meaning of emotional stimuli; (b) impaired direct regulation of emotional responses, which might be common for personality disorders;

Indexed as

Self-ControlAdultAmygdalaBorderline Personality DisorderConnectomeEmotionsFemaleHumansMagnetic Resonance ImagingPrefrontal CortexYoung AdultAmygdalaBPDEmotion regulationFunctional connectivityResting-state fMRI

Identifiers

PMID28039553
PMCPMC5561271
OpenAlexW2564330251

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.