ArticleInternational journal of clinical oncology2017
Hyaluronic acid binding protein 1 overexpression is an indicator for disease-free survival in cervical cancer.
Article in International journal of clinical oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 10 citations in OpenAlex.
- Trial
- Unveiling the mysteries of C1QBP in gynecological tumors (Review).Molecular and clinical oncology · 2026Review
- Role of Hyaluronic Acid in Selected Malignant Neoplasms in Women.Biomedicines · 2023Review
- The role of hyaluronan in renal cell carcinoma.Frontiers in immunology · 2023Review
- An approach to p32/gC1qR/HABP1: a multifunctional protein with an essential role in cancer.Journal of cancer research and clinical oncology · 2022Review
- Prognostic and functional role of hyaluronan-binding protein 1 in pancreatic ductal adenocarcinoma.Oncology letters · 2022Article
- p32/C1QBP regulates OMA1-dependent proteolytic processing of OPA1 to maintain mitochondrial connectivity related to mitochondrial dysfunction and apoptosis.Scientific reports · 2020Article
- Better survival is observed in cervical cancer patients positive for specific anti-glycan antibodies and receiving brachytherapy.Gynecologic oncology · 2020Article
- Systematic Multiomics Analysis of Alterations in C1QBP mRNA Expression and Relevance for Clinical Outcomes in Cancers.Journal of clinical medicine · 2019Article
- Up-regulated of Angiopoietin-Like Protein 4 Predicts Poor Prognosis in Cervical Cancer.Journal of Cancer · 2019Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgoundHyaluronic acid binding protein 1 (HABP1) is reported to overexpress in various cancer tissues and may therefore contribute to oncogenesis. However, the status of HABP1 expression in cervical cancer (CC) remains unknown. The aim of this study was to investigate the role of HABP1 and its relationship with clinical characteristics in patients with CC.
methodsImmunohistochemistry was used to explore the expression of HABP1 in 30 cervical intra-epithelial neoplasia (CIN) and 118 CC specimens compared to 10 normal cervical specimens.
resultsHABP1 expression was found to be positively higher in CC than in CIN2/3 cases (P = 0.020). Moreover, clinicopathological analysis showed that HABP1 overexpression was associated with advanced FIGO stage (P = 0.001), poor histologic grade (P = 0.013), large tumor size (P = 0.025), LVSI (P = 0.024), deep stromal infiltration (P = 0.001), and lymph node metastasis (P = 0.023). Multivariate analysis suggested that HABP1 overexpression was an independent factor for disease-free survival (DFS) (hazard ratio 3.082; 95% confidence interval 1.372-7.501; P = 0.007).
conclusionsThe present data provide evidence that HABP1 overexpression predicts CC with high-risk factors and may therefore serve as a new molecular marker for the prediction of DFS in these patients.
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