ArticleOncotarget2017
Genetic polymorphisms in the telomere length-related gene ACYP2 are associated with the risk of colorectal cancer in a Chinese Han population.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Associations between polymorphisms of the ACYP2 gene and Liver cancer risk: A case-control study and meta-analysis.Molecular genetics & genomic medicine · 2019Pooled it
- Genetic overlap between schizophrenia and constipation: insights from a genome-wide association study in a European population.Annals of general psychiatry · 2025Article
- Association between ACYP2 polymorphisms and the risk of renal cell cancer.Molecular genetics & genomic medicine · 2019Article
- The influence of ACYP2 polymorphisms on gastrointestinal cancer susceptibility in the Chinese Han population.Molecular genetics & genomic medicine · 2019Article
- Integrative analysis of gene expression profiles reveals distinct molecular characteristics in oral tongue squamous cell carcinoma.Oncology letters · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the association between single nucleotide polymorphisms (SNPs) in ACYP2, which has been associated with telomere length in several types of cancer, and the risk of CRC in a Chinese Han population. In a case-control study that included 247 cases and 300 healthy controls, 14 SNPs in ACYP2 were selected and genotyped using the Sequenom MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression after adjusting for age and gender. We determined that rs843711 and rs843706 were associated with an increased risk of CRC (rs843711: OR = 1.376, 95% CI = 1.082-1.749, p = 0.009; rs843706: OR = 1.361, 95% CI = 1.069-1.733, p = 0.012). Additionally, rs6713088, rs843645, rs843711, and rs843706 were associated with an increased risk of CRC under additive and recessive models (p < 0.05). Finally, the "TTCTCGCC" and "CG" haplotypes decreased the risk of CRC, while the "AG" haplotype increase the risk of CRC. The association between rs843711 and CRC remained significant after Bonferroni correction for multiple comparisons (p ≤ 0.00036). Our data shed new light on the associations between genetic variants in the ACYP2 gene and CRC susceptibility in a Chinese Han population.
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