ArticleJournal of medical genetics2017
A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
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Article in Journal of medical genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
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8citing papers in PubMed, 3 pooled it
1.1field-weighted citation impact, top 18% of its field
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Who cites it
8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 14 citations in OpenAlex.
- Genome-Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants.Journal of the American Heart Association · 2024Pooled it
- A large genome-wide association study of QT interval length utilizing electronic health records.Genetics · 2022Pooled it
- Pharmacogenomic markers associated with drug-induced QT prolongation: a systematic review.PharmacogenomicsPooled it
- Advancements in genetic research by the Hispanic Community Health Study/Study of Latinos: A 10-year retrospective review.HGG advances · 2025Review
- Precision Medicine in Antidepressants Treatment.Handbook of experimental pharmacology · 2023Review
- Objectives, design and main findings until 2020 from the Rotterdam Study.European journal of epidemiology · 2020Article
- Genomic approaches for the elucidation of genes and gene networks underlying cardiovascular traits.Biophysical reviews · 2018Review
- The Rotterdam Study: 2018 update on objectives, design and main results.European journal of epidemiology · 2017Article
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Authors and funding
67 authors at 20 institutions in 5 countries.
Raymond NoordamDepartment of Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
Colleen M SitlaniDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Christy L AveryDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
James D StewartDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Stephanie M GogartenDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
Kerri L WigginsDepartment of Medicine, University of Washington, Seattle, Washington, USA.ORCID 0000-0003-2749-1279
Stella TrompetDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Helen R WarrenDepartment of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London, UK.
Fangui SunDepartment of Biostatistics, School of Public Health, Boston University, Boston, Massachusetts, USA.
Daniel S EvansCalifornia Pacific Medical Center Research Institute, San Francisco, California, USA.
Xiaohui LiInstitute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Jin LiDivision of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Palo Alto, California, USA.
Albert V SmithIcelandic Heart Association, Kopavogur, Iceland.
Joshua C BisDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Jennifer A BrodyDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Evan L BuschDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Mark J CaulfieldDepartment of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London, UK.
Yii-Der I ChenInstitute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Steven R CummingsCalifornia Pacific Medical Center Research Institute, San Francisco, California, USA.
L Adrienne CupplesDepartment of Biostatistics, School of Public Health, Boston University, Boston, Massachusetts, USA.
Qing DuanDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.
Oscar H FrancoDepartment of Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
Rául Méndez-GiráldezDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Tamara B HarrisLaboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA.
Susan R HeckbertDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Diana van HeemstDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Albert HofmanDepartment of Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
James S FloydDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Jan A KorsDepartment of Medical Informatics, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
Lenore J LaunerLaboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA.
Yun LiDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.
Ruifang Li-GaoDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Leslie A LangeDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.
Henry J LinInstitute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Renée de MutsertDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Melanie D NapierDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Christopher Newton-ChehFramingham Heart Study, Framingham, Massachusetts, USA.
Neil PoulterInternational Centre for Circulatory Health, Imperial College London, London, UK.
Alexander P ReinerDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Kenneth M RiceDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
Jeffrey RoachResearch Computing Center, University of North Carolina, Chapel Hill, North Carolina, USA.
Carlos J RodriguezDepartment of Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Frits R RosendaalDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Naveed SattarFaculty of Medicine, BHF Glasgow Cardiovascular Research Centre, Glasgow, UK.
Peter SeverInternational Centre for Circulatory Health, Imperial College London, London, UK.
Amanda A SeyerleDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
P Eline SlagboomDepartment of Medical Statistics and Bioinformatics, Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Elsayed Z SolimanEpidemiological Cardiology Research Center (EPICARE), Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Nona SotoodehniaDepartment of Medicine, University of Washington, Seattle, Washington, USA.
David J StottInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Til StürmerDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Kent D TaylorInstitute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Timothy A ThorntonDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
André G UitterlindenDepartment of Internal Medicine, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
Kirk C WilhelmsenDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Cathy C LaurieDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
Yongmei LiuDivision of Public Health Sciences, Department of Epidemiology and Prevention, Wake Forest University, Winston-Salem, North Carolina, USA.
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Patricia B MunroeDepartment of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London, UK.
Jerome I RotterInstitute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Ramachandran S VasanFramingham Heart Study, Framingham, Massachusetts, USA.
Bruce M PsatyDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Bruno H StrickerDepartment of Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
Eric A WhitselDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
University of North Carolina at Chapel Hill · USUniversity of Washington · USLeiden University Medical Center · NLThe Lundquist Institute · USBoston University · USErasmus MC · NLQueen Mary University of London · GBWake Forest University · USCalifornia Pacific Medical Center · USImperial College London · GBNational Institute on Aging · USUniversity of Iceland · ISBrigham and Women's Hospital · USBritish Heart Foundation · GBBroad Institute · USDutch Health Care Inspectorate · NLGroup Health Cooperative · USHarvard University · USJackson Memorial Hospital · USStanford University · US
Funding
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MInstitute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MTraining Program in Cancer EpidemiologyT32CA009001 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI A. Heather Eliassen, Meir Stampfer · 1985 to 2026
$17.3MUCLA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR033176 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2011 to 2011
$15.5MEpidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8MMulti-Ethnic Study of Atherosclerosis (MESA) StudyR01HL071205 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI ROTTER, JEROME I · 2003 to 2007
$10.4MExceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5MIntramural NIH HHS Z01 AG007380Medical Research Council MR/K006584/1NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001079NCI NIH HHS T32 CA009001NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1 RR033176NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01 HG005152NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201000031CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201300005CNHLBI NIH HHS HHSN268201300046CNHLBI NIH HHS HHSN268201300047CNHLBI NIH HHS HHSN268201300049CNHLBI NIH HHS HHSN268201300050CNHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS K23 HL080025NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N02 HL064278NHLBI NIH HHS R00 HL098458NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL071051NHLBI NIH HHS R01 HL071205NHLBI NIH HHS R01 HL071250NHLBI NIH HHS R01 HL071251NHLBI NIH HHS R01 HL071252NHLBI NIH HHS R01 HL071258NHLBI NIH HHS R01 HL071259NHLBI NIH HHS R01 HL085251NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL120393NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG032098NIDDK NIH HHS P30 DK063491NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R01 ES017794NIGMS NIH HHS P01 GM099568
Abstract
backgroundIncreased heart rate and a prolonged QT interval are important risk factors for cardiovascular morbidity and mortality, and can be influenced by the use of various medications, including tricyclic/tetracyclic antidepressants (TCAs). We aim to identify genetic loci that modify the association between TCA use and RR and QT intervals. METHODS AND
resultsWe conducted race/ethnic-specific genome-wide interaction analyses (with HapMap phase II imputed reference panel imputation) of TCAs and resting RR and QT intervals in cohorts of European (n=45 706; n=1417 TCA users), African (n=10 235; n=296 TCA users) and Hispanic/Latino (n=13 808; n=147 TCA users) ancestry, adjusted for clinical covariates. Among the populations of European ancestry, two genome-wide significant loci were identified for RR interval: rs6737205 in
conclusionsAmong Europeans, TCA interactions with variants in
Indexed as
ElectrocardiographyGenome-Wide Association StudyPharmacogeneticsAgedAgingAntidepressive Agents, TricyclicFemaleGenetic LociHeartHumansMaleMiddle AgedAntidepressive Agents, Tricyclicdrug-gene interactionGenome-wideQT interval electrocardiographyRR intervaltri/tetracyclic antidepressants
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