Evidence map›Paper›PMID 28039281›Full record

ArticleCirculation. Arrhythmia and electrophysiology2017

Association of Rate-Dependent Conduction Block Between Eccentric Coronary Sinus to Left Atrial Connections With Inducible Atrial Fibrillation and Flutter.

Dong Huang, Joseph E Marine, Jing-Bo Li, Tarek Zghaib, Esra Gucuk Ipek, Sunil Sinha, David D Spragg, Hiroshi Ashikaga, Ronald D Berger, Hugh Calkins and 1 more

Erratum issued Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03646643 (Prospective Elimination Of Distal Coronary Sinus-Left Atrial Connections for Atrial Fibrillation Ablation Trial), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03646643 nacompletednot on this mapstarted 2018, after this paper: background citation

Prospective Elimination Of Distal Coronary Sinus-Left Atrial Connections for Atrial Fibrillation Ablation Trial

TypeinterventionalSponsorUniversity of PennsylvaniaRan2018 to 2021Enrolled35ConditionsAtrial Fibrillation, Arrhythmias, CardiacArmsStandard Atrial fibrillation ablation, Coronary sinus to left atrium connection elimination
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Circumferential pulmonary vein isolation with adjunctive linear ablation vs. circumferential pulmonary vein isolation alone for long-standing persistent atrial fibrillation: a randomized pilot study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Trial
  2. PRECAF Randomized Controlled Trial.Circulation. Arrhythmia and electrophysiology · 2021
    Trial
  3. Article
  4. Evolution in electrophysiology 100 years after Einthoven: translational and computational innovations in rhythm control of atrial fibrillation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Review
  5. Convergent Double Coronary Sinus Potentials During Atrial Tachycardia.The Journal of innovations in cardiac rhythm management · 2023
    Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Dong HuangFrom the Department of Cardiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, China (D.H., J.-b.L.); Section for Cardiac Electrophysiology, Department of Medicine/Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (D.H., J.E.M., T.Z., E.G.I., S.S., D.D.S., H.A., R.D.B., H.C., S.N.); Section for Cardiac Electrophysiology, Department of Medicine/Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia (S.N.).
Joseph E MarineFrom the Department of Cardiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, China (D.H., J.-b.L.); Section for Cardiac Electrophysiology, Department of Medicine/Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (D.H., J.E.M., T.Z., E.G.I., S.S., D.D.S., H.A., R.D.B., H.C., S.N.); Section for Cardiac Electrophysiology, Department of Medicine/Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia (S.N.).
Jing-Bo LiFrom the Department of Cardiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, China (D.H., J.-b.L.); Section for Cardiac Electrophysiology, Department of Medicine/Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (D.H., J.E.M., T.Z., E.G.I., S.S., D.D.S., H.A., R.D.B., H.C., S.N.); Section for Cardiac Electrophysiology, Department of Medicine/Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia (S.N.).
Tarek ZghaibFrom the Department of Cardiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, China (D.H., J.-b.L.); Section for Cardiac Electrophysiology, Department of Medicine/Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (D.H., J.E.M., T.Z., E.G.I., S.S., D.D.S., H.A., R.D.B., H.C., S.N.); Section for Cardiac Electrophysiology, Department of Medicine/Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia (S.N.).
Esra Gucuk IpekFrom the Department of Cardiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, China (D.H., J.-b.L.); Section for Cardiac Electrophysiology, Department of Medicine/Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (D.H., J.E.M., T.Z., E.G.I., S.S., D.D.S., H.A., R.D.B., H.C., S.N.); Section for Cardiac Electrophysiology, Department of Medicine/Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia (S.N.).
Sunil SinhaFrom the Department of Cardiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, China (D.H., J.-b.L.); Section for Cardiac Electrophysiology, Department of Medicine/Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (D.H., J.E.M., T.Z., E.G.I., S.S., D.D.S., H.A., R.D.B., H.C., S.N.); Section for Cardiac Electrophysiology, Department of Medicine/Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia (S.N.).
David D SpraggFrom the Department of Cardiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, China (D.H., J.-b.L.); Section for Cardiac Electrophysiology, Department of Medicine/Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (D.H., J.E.M., T.Z., E.G.I., S.S., D.D.S., H.A., R.D.B., H.C., S.N.); Section for Cardiac Electrophysiology, Department of Medicine/Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia (S.N.).
Hiroshi AshikagaFrom the Department of Cardiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, China (D.H., J.-b.L.); Section for Cardiac Electrophysiology, Department of Medicine/Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (D.H., J.E.M., T.Z., E.G.I., S.S., D.D.S., H.A., R.D.B., H.C., S.N.); Section for Cardiac Electrophysiology, Department of Medicine/Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia (S.N.).
Ronald D BergerFrom the Department of Cardiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, China (D.H., J.-b.L.); Section for Cardiac Electrophysiology, Department of Medicine/Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (D.H., J.E.M., T.Z., E.G.I., S.S., D.D.S., H.A., R.D.B., H.C., S.N.); Section for Cardiac Electrophysiology, Department of Medicine/Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia (S.N.).
Hugh CalkinsFrom the Department of Cardiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, China (D.H., J.-b.L.); Section for Cardiac Electrophysiology, Department of Medicine/Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (D.H., J.E.M., T.Z., E.G.I., S.S., D.D.S., H.A., R.D.B., H.C., S.N.); Section for Cardiac Electrophysiology, Department of Medicine/Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia (S.N.).
Saman NazarianFrom the Department of Cardiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, China (D.H., J.-b.L.); Section for Cardiac Electrophysiology, Department of Medicine/Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (D.H., J.E.M., T.Z., E.G.I., S.S., D.D.S., H.A., R.D.B., H.C., S.N.); Section for Cardiac Electrophysiology, Department of Medicine/Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia (S.N.). saman.nazarian@uphs.upenn.edu.
Shanghai Sixth People's Hospital · CN

Funding

ANCILLARY STUDY OF SUBSTRATE AND INTERVENTION MECHANISMS FOR MALIGNANT ARRHYTHMIAR01HL116280 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI NAZARIAN, SAMAN · 2013 to 2016
$1.2M
Applications of Magnetic Resonance for Management of Ventricular TachycardiaK23HL089333 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI NAZARIAN, SAMAN · 2010 to 2014
$686k
NHLBI NIH HHS K23 HL089333NHLBI NIH HHS R01 HL116280
6 · The paper itself

Abstract

backgroundWe sought to describe the prevalence and variability of coronary sinus (CS) and left atrial (LA) myocardium connections, their susceptibility to rate-dependent conduction block, and association with atrial fibrillation (AF) and flutter induction. METHODS AND

resultsThe study cohort included 30 consecutive AF patients (age 63.3±10.5 years, 63% male). Multipolar catheters were positioned in the CS, high right atrium (HRA), and LA parallel to and near the CS. Trains of 10 pacing stimuli were delivered during sinus rhythm from each of the following sites: CS proximal (CS

conclusionsRate-dependent eccentric CS-LA conduction block is associated with AF/atrial flutter induction in patients with drug-refractory AF undergoing ablation. The presence of dual muscular CS-LA connections, coupled with unidirectional block in one limb, seems to serve as a substrate for single or multiple reentry beats, and arrhythmia induction.

Indexed as

AgedAtrial FibrillationAtrial FlutterCardiac CatheterizationCardiac Pacing, ArtificialCatheter AblationCoronary SinusFemaleHeart AtriaHeart BlockHeart Conduction SystemHeart RateHumansMaleMiddle Agedatrial fibrillationatrial fluttercatheter ablationcoronary sinusmyocardium

Identifiers

PMID28039281
PMCPMC5218631
OpenAlexW2563420185

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.