ArticleBritish journal of cancer1989
Structure and expression of nuclear oncogenes in multi-stage thyroid tumorigenesis.
Article in British journal of cancer, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 35 citations in OpenAlex.
- cMYC expression in thyroid follicular cell-derived carcinomas: a role in thyroid tumorigenesis.Diagnostic pathology · 2017Article
- Medullary thyroid carcinoma: targeted therapies and future directions.Journal of oncology · 2009Article
- Insular and anaplastic carcinoma of the thyroid: a 45-year comparative study at a single institution and a review of the significance of p53 and p21.Annals of surgery · 2000Article
- Human thyroid cancer cells as a source of iso-genic, iso-phenotypic cell lines with or without functional p53.British journal of cancer · 1999Article
- Transplantable rat thyroid cancer cell line FRTC transformed with muramyl dipeptide.British journal of cancer · 1997Article
- Immunohistochemical Localization of p53 in Human Thyroid Neoplasms: Correlation with Biological Behavior.Endocrine pathology · 1997Article
- Dissociation of thyrotropin receptor function and thyrotropin dependency in rat thyroid tumour cell lines derived from FRTL-5.British journal of cancer · 1996Article
- Expression of c-erbB-2 protein in papillary thyroid carcinomas.British journal of cancer · 1992Article
- Image analysis quantitation of immunoreactive retinoblastoma protein in human thyroid neoplasms with a streptavidin-biotin-peroxidase staining technique.The American journal of pathology · 1991Article
- Cytogenetic and molecular genetic studies of follicular and papillary thyroid cancers.The Journal of clinical investigation · 1991Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have investigated the possibility that structural alterations of the 'nuclear' oncogene family (c-myc, N-myc, L-myc, fos, myb and p53) leading to aberrant expression might, as in several other tumour types, play a role in the multi-stage development of tumorigenesis in the human thyroid follicular cell. Direct analysis of expression by slot and Northern blot RNA hybridisation showed that normal thyroid expresses surprisingly high levels of fos, and to a lesser extent c-myc, c-myc expression was markedly increased in all tumours, both benign and malignant, but no increase was seen in any other nuclear oncogene. fos expression was reduced specifically in one type of malignant tumour-follicular carcinoma-in inverse correlation with differentiation. Southern blot analysis showed no evidence of rearrangement or amplification of c-myc, or of any other 'nuclear' oncogene in any thyroid tumour. We conclude that there is no evidence that a primary abnormality of these genes plays a role in thyroid follicular cell tumorigenesis and suggest that the observed changes in expression can be adequately explained as secondary consequences of the tumour phenotype.
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