ArticleBlood2017
Abnormal joint and bone wound healing in hemophilia mice is improved by extending factor IX activity after hemarthrosis.
Article in Blood, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 47 citations in OpenAlex.
- Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant.The New England journal of medicine · 2017Trial
- Bone mineral density, bone remodeling biomarkers, and hemostatic correlates in hemophilia and von Willebrand disease.Blood advances · 2026Article
- Activated partial thromboplastin time is a potential risk factor for prolonged chest drain placement following surgery for primary spontaneous pneumothorax: a case-control study.General thoracic and cardiovascular surgery · 2026Article
- Function of epigenetic modifications in wound healing and potential therapies (Review).International journal of molecular medicine · 2025Review
- Activated factor X delivered by adeno-associated virus significantly inhibited bleeding and alleviated hemophilic synovitis in hemophilic mice.Gene therapy · 2024Article
- Activation of the Acute-Phase Response in Hemophilia.Thrombosis and haemostasis · 2023Article
- Pathogenesis and treatment of osteoporosis in patients with hemophilia.Archives of osteoporosis · 2023Review
- Extracellular vesicles modulate key signalling pathways in refractory wound healing.Burns & trauma · 2023Review
- Low Bone Mineral Density in Hemophiliacs.Frontiers in medicine · 2022Review
- On-demand treatment with the iron chelator deferasirox is ineffective in preventing blood-induced joint damage in haemophilic mice.Haemophilia : the official journal of the World Federation of Hemophilia · 2021Article
- In vivo enrichment of genetically manipulated platelets for murine hemophilia B gene therapy.Journal of cellular physiology · 2021Article
- Advances on Graphene-Based Nanomaterials and Mesenchymal Stem Cell-Derived Exosomes Applied in Cutaneous Wound Healing.International journal of nanomedicine · 2021Review
- Initial joint bleed volume in a delayed on-demand treatment setup correlates with subsequent synovial changes in hemophilic mice.Animal models and experimental medicine · 2020Article
- Proteoglycan synthesis rate as a novel method to measure blood-induced cartilage degeneration in non-haemophilic and haemophilic rats.Haemophilia : the official journal of the World Federation of Hemophilia · 2020Article
- A Translational Study of TNF-Alpha Antagonists as an Adjunctive Therapy for Preventing Hemophilic Arthropathy.Journal of clinical medicine · 2019Article
- Mechanisms of vascular permeability and remodeling associated with hemarthrosis in factor VIII-deficient mice.Journal of thrombosis and haemostasis : JTH · 2019Article
- Hemophilia A and B mice, but not VWFScientific reports · 2019Article
- Novel Piperazino-Enaminones Decrease Pro-inflammatory Cytokines Following Hemarthrosis in a Hemophilia Mouse Model.Inflammation · 2019Article
- Nongenotoxic antibody-drug conjugate conditioning enables safe and effective platelet gene therapy of hemophilia A mice.Blood advances · 2019Article
- Timely and large dose of clotting factor IX provides better joint wound healing after hemarthrosis in hemophilia B mice.International journal of hematology · 2019Article
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wound healing requires interactions between coagulation, inflammation, angiogenesis, cellular migration, and proliferation. Healing in dermal wounds of hemophilia B mice is delayed when compared with hemostatically normal wild-type (WT) mice, with abnormal persistence of iron deposition, inflammation, and neovascularity. We observed healing following induced joint hemorrhage in WT and factor IX (FIX) knockout (FIX
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.