Evidence map›Paper›PMID 28038965›Full record

ArticleMagnetic resonance imaging2017

Inversion recovery ultrashort echo time magnetic resonance imaging: A method for simultaneous direct detection of myelin and high signal demonstration of iron deposition in the brain - A feasibility study.

Vipul R Sheth, Shujuan Fan, Qun He, Yajun Ma, Jacopo Annese, Robert Switzer, Jody Corey-Bloom, Graeme M Bydder, Jiang Du

Abstract read
In one paragraph

Article in Magnetic resonance imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. High-resolution 3D ultra-short echo time MRI with Rosette k-space pattern for brain iron content mapping.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2023
    Article
  4. Article
  5. Ultra-short TMagnetic resonance in medicine · 2023
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. The Role of Advanced Magnetic Resonance Imaging Techniques in Multiple Sclerosis Clinical Trials.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Vipul R ShethDepartment of Radiology, University of California, San Diego, CA, United States.
Shujuan FanDepartment of Radiology, University of California, San Diego, CA, United States.
Qun HeDepartment of Radiology, University of California, San Diego, CA, United States.
Yajun MaDepartment of Radiology, University of California, San Diego, CA, United States.
Jacopo AnneseThe Institute for Brain and Society, San Diego, CA, United States.
Robert SwitzerNeuroScience Associates, Inc., Knoxville, TN, United States.
Jody Corey-BloomDepartment of NeuroSciences, University of California, San Diego, United States.
Graeme M BydderDepartment of Radiology, University of California, San Diego, CA, United States.
Jiang DuDepartment of Radiology, University of California, San Diego, CA, United States. Electronic address: jiangdu@ucsd.edu.
University of California, San Diego · US

Funding

Traning Clinical Scientists in Radiological ImagingT32EB005970 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Eric Y Chang, Rebecca Ann Rakow-Penner · 2007 to 2026
$3.2M
UTE Magnetic Resonance Imaging: New Biomarkers for Multiple SclerosisR01NS092650 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DU, JIANG · 2015 to 2019
$1.9M
NIBIB NIH HHS T32 EB005970NINDS NIH HHS R01 NS092650
6 · The paper itself

Abstract

Multiple sclerosis (MS) causes demyelinating lesions in the white matter and increased iron deposition in the subcortical gray matter. Myelin protons have an extremely short T2* (<1ms) and are not directly detected with conventional clinical magnetic resonance (MR) imaging sequences. Iron deposition also reduces T2*, leading to reduced signal on clinical sequences. In this study we tested the hypothesis that the inversion recovery ultrashort echo time (IR-UTE) pulse sequence can directly and simultaneously image myelin and iron deposition using a clinical 3T scanner. The technique was first validated on a synthetic myelin phantom (myelin powder in D

Indexed as

Image Processing, Computer-AssistedMagnetic Resonance ImagingAdultAgedBrainCadaverFeasibility StudiesFemaleGray MatterHealthy VolunteersHumansIronMaleMiddle AgedMultiple SclerosisMyelin SheathIronWaterIronMagnetic resonance imagingMultiple sclerosisMyelinUltrashort echo time

Identifiers

PMID28038965
PMCPMC5503675
OpenAlexW2562186381

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.