Evidence map›Paper›PMID 28038734›Full record

ArticleBiophysical journal2017

Partially Assembled Nucleosome Structures at Atomic Detail.

Georgy N Rychkov, Andrey V Ilatovskiy, Igor B Nazarov, Alexey V Shvetsov, Dmitry V Lebedev, Alexander Y Konev, Vladimir V Isaev-Ivanov, Alexey V Onufriev

Open access · bronzeAbstract read
In one paragraph

Article in Biophysical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
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  3. Article
  4. Article
  5. Article
  6. Sequence Dependence in Nucleosome Dynamics.The journal of physical chemistry. B · 2024
    Article
  7. Article
  8. Article
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  12. Review
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  19. Review
  20. The role of histone tails in nucleosome stability: An electrostatic perspective.Computational and structural biotechnology journal · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Georgy N RychkovDivision of Molecular and Radiation Biophysics, B.P. Konstantinov Petersburg Nuclear Physics Institute, National Research Center "Kurchatov Institute", Orlova Roscha, Gatchina, Leningrad District, Russia; Institute of Physics, Nanotechnology and Telecommunications, NRU Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia.
Andrey V IlatovskiyDivision of Molecular and Radiation Biophysics, B.P. Konstantinov Petersburg Nuclear Physics Institute, National Research Center "Kurchatov Institute", Orlova Roscha, Gatchina, Leningrad District, Russia; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California.
Igor B NazarovInstitute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia.
Alexey V ShvetsovDivision of Molecular and Radiation Biophysics, B.P. Konstantinov Petersburg Nuclear Physics Institute, National Research Center "Kurchatov Institute", Orlova Roscha, Gatchina, Leningrad District, Russia; Institute of Applied Mathematics and Mechanics, NRU Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia.
Dmitry V LebedevDivision of Molecular and Radiation Biophysics, B.P. Konstantinov Petersburg Nuclear Physics Institute, National Research Center "Kurchatov Institute", Orlova Roscha, Gatchina, Leningrad District, Russia.
Alexander Y KonevDivision of Molecular and Radiation Biophysics, B.P. Konstantinov Petersburg Nuclear Physics Institute, National Research Center "Kurchatov Institute", Orlova Roscha, Gatchina, Leningrad District, Russia.
Vladimir V Isaev-IvanovDivision of Molecular and Radiation Biophysics, B.P. Konstantinov Petersburg Nuclear Physics Institute, National Research Center "Kurchatov Institute", Orlova Roscha, Gatchina, Leningrad District, Russia.
Alexey V OnufrievDepartments of Computer Science and Physics, Virginia Tech, Blacksburg, Virginia. Electronic address: alexey@cs.vt.edu.
Petersburg Nuclear Physics Institute · RUInstitute of Cytology · RUPeter the Great St. Petersburg Polytechnic University · RUVirginia Tech · US

Funding

Analytical Electrostatics: Methods and Biological Applications.R01GM076121 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI ONUFRIEV, ALEXEY VLAD · 2006 to 2014
$2.6M
DNA - DNA interactions with atomic detailR01GM099450 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI BAKER, NATHAN A., ONUFRIEV, ALEXEY VLAD · 2012 to 2015
$1.3M
NIGMS NIH HHS R01 GM076121NIGMS NIH HHS R01 GM099450
6 · The paper itself

Abstract

The evidence is now overwhelming that partially assembled nucleosome states (PANS) are as important as the canonical nucleosome structure for the understanding of how accessibility to genomic DNA is regulated in cells. We use a combination of molecular dynamics simulation and atomic force microscopy to deliver, in atomic detail, structural models of three key PANS: the hexasome (H2A·H2B)·(H3·H4)

Indexed as

Microscopy, Atomic ForceMolecular Dynamics SimulationDNAGenomicsNucleic Acid ConformationNucleosomesDNANucleosomes

Identifiers

PMID28038734
PMCPMC5300784
OpenAlexW2285306960

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.