ArticlePLoS neglected tropical diseases2016
First Identification and Description of Rickettsioses and Q Fever as Causes of Acute Febrile Illness in Nicaragua.
Article in PLoS neglected tropical diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Rickettsial seropositivity in Lao PDR smallholder livestock farms: Implications for animal and human health.One health (Amsterdam, Netherlands) · 2026Article
- Antibody Prevalence and Risk Factors Associated withPathogens (Basel, Switzerland) · 2022Article
- Spotted Fever Group Rickettsioses in Central America: The Research and Public Health Disparity among Socioeconomic Lines.Insects · 2022Review
- Review
- Ticks and Tick-Borne Diseases in Central America and the Caribbean: A One Health Perspective.Pathogens (Basel, Switzerland) · 2021Review
- Spotted fever diagnosis: Experience from a South Indian center.Pathogens and global health · 2021Article
- Optimization and Evaluation of a Multiplex Quantitative PCR Assay for Detection of Nucleic Acids in Human Blood Samples from Patients with Spotted Fever Rickettsiosis, Typhus Rickettsiosis, Scrub Typhus, Monocytic Ehrlichiosis, and Granulocytic Anaplasmosis.Journal of clinical microbiology · 2020Article
- Rickettsioses as Major Etiologies of Unrecognized Acute Febrile Illness, Sabah, East Malaysia.Emerging infectious diseases · 2020Article
- Evidence of Q Fever and Rickettsial Disease in Chile.Tropical medicine and infectious disease · 2020Article
- Comparison of Commercial Enzyme-Linked Immunosorbent Assay and Immunofluorescence Assay for Diagnosis of AcuteVector borne and zoonotic diseases (Larchmont, N.Y.) · 2020Article
- Etiologies of Acute Undifferentiated Febrile Illness in Bangkok, Thailand.The American journal of tropical medicine and hygiene · 2019Article
- Epidemiology of acute febrile illness in Latin America.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2018Review
- Development and Clinical Validation of a Multiplex Real-Time Quantitative PCR Assay for Human Infection by Anaplasma phagocytophilum and Ehrlichia chaffeensis.Tropical medicine and infectious disease · 2018Article
- A review of the genusResearch and reports in tropical medicine · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundRickettsial infections and Q fever present similarly to other acute febrile illnesses, but are infrequently diagnosed because of limited diagnostic tools. Despite sporadic reports, rickettsial infections and Q fever have not been prospectively studied in Central America. METHODOLOGY/PRINCIPAL
findingsWe enrolled consecutive patients presenting with undifferentiated fever in western Nicaragua and collected epidemiologic and clinical data and acute and convalescent sera. We used ELISA for screening and paired sera to confirm acute (≥4-fold rise in titer) spotted fever and typhus group rickettsial infections and Q fever as well as past (stable titer) infections. Characteristics associated with both acute and past infection were assessed. CONCLUSIONS/SIGNIFICANCE: We enrolled 825 patients and identified acute rickettsial infections and acute Q fever in 0.9% and 1.3%, respectively. Clinical features were non-specific and neither rickettsial infections nor Q fever were considered or treated. Further study is warranted to define the burden of these infections in Central America.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.