ArticlePLoS neglected tropical diseases2016
The Global Phylogeography of Lyssaviruses - Challenging the 'Out of Africa' Hypothesis.
Article in PLoS neglected tropical diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- A review of rabies in Southern African wildlife: Reservoir hosts, transmission dynamics, and control implications.Open veterinary journal · 2026Review
- Phylogenetic and motif-based genomic analysis of Mokola virus: implications for regional divergence and data gaps.BMC genomic data · 2025Article
- Lyssavirus Antibody Detection in Cave-Dwelling Bats on Cat Ba Island, Vietnam: Implications for Zoonotic Surveillance.Veterinary sciences · 2025Article
- Two Decades of Human Rabies in Brazil: Epidemiological Trends, Emerging Risks and Treatment Challenges.Revista da Sociedade Brasileira de Medicina Tropical · 2025Article
- Minimal risk ofFrontiers in microbiology · 2025Article
- Toward the Development of a Pan-Lyssavirus Vaccine.Viruses · 2024Article
- Phylogeographic Aspects of Bat Lyssaviruses in Europe: A Review.Pathogens (Basel, Switzerland) · 2023Review
- Rabies in a postpandemic world: resilient reservoirs, redoubtable riposte, recurrent roadblocks, and resolute recidivism.Animal diseases · 2023Review
- Article
- Quantifying intra- and inter-species contact rates at supplemental feeding sites in Ethiopia to inform rabies maintenance potential of multiple host species.Transboundary and emerging diseases · 2022Article
- Opportunities and Limitations of Molecular Methods for Studying Bat-Associated Pathogens.Microorganisms · 2022Review
- Article
- Renewed Public Health Threat from Emerging Lyssaviruses.Viruses · 2021Article
- Assessing Rabies Vaccine Protection against a Novel Lyssavirus, Kotalahti Bat Lyssavirus.Viruses · 2021Article
- Possibility for reverse zoonotic transmission of SARS-CoV-2 to free-ranging wildlife: A case study of bats.PLoS pathogens · 2020Review
- Rabies virus diversification in aerial and terrestrial mammals.Genetics and molecular biology · 2020Article
- Human rabies associated with domestic cat exposures in South Africa, 1983-2018.Journal of the South African Veterinary Association · 2020Article
- The Serological Prevalence of Rabies Virus-Neutralizing Antibodies in the Bat Population on the Caribbean Island of Trinidad.Viruses · 2020Article
- Rabies virus-neutralising antibodies in healthy, unvaccinated individuals: What do they mean for rabies epidemiology?PLoS neglected tropical diseases · 2020Review
- Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rabies virus kills tens of thousands of people globally each year, especially in resource-limited countries. Yet, there are genetically- and antigenically-related lyssaviruses, all capable of causing the disease rabies, circulating globally among bats without causing conspicuous disease outbreaks. The species richness and greater genetic diversity of African lyssaviruses, along with the lack of antibody cross-reactivity among them, has led to the hypothesis that Africa is the origin of lyssaviruses. This hypothesis was tested using a probabilistic phylogeographical approach. The nucleoprotein gene sequences from 153 representatives of 16 lyssavirus species, collected between 1956 and 2015, were used to develop a phylogenetic tree which incorporated relevant geographic and temporal data relating to the viruses. In addition, complete genome sequences from all 16 (putative) species were analysed. The most probable ancestral distribution for the internal nodes was inferred using three different approaches and was confirmed by analysis of complete genomes. These results support a Palearctic origin for lyssaviruses (posterior probability = 0.85), challenging the 'out of Africa' hypothesis, and suggest three independent transmission events to the Afrotropical region, representing the three phylogroups that form the three major lyssavirus clades.
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