ArticlePloS one2016
Production of Secondary Metabolites in Extreme Environments: Food- and Airborne Wallemia spp. Produce Toxic Metabolites at Hypersaline Conditions.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Wallemia orionensis sp. nov., a Xerophilic and Halotolerant Fungus Isolated from Air Environment.Current microbiology · 2026Article
- Ocotea odorifera extract: antimicrobial and antibiofilm activities, phytochemical aspects, cytotoxicity and anti-inflammatory potential of an endangered plant species.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
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- Multi-omics analyses reveal rumen microbes and secondary metabolites that are unique to livestock species.mSystems · 2024Article
- Microbiome and metagenomic analysis of Lake Hillier Australia reveals pigment-rich polyextremophiles and wide-ranging metabolic adaptations.Environmental microbiome · 2022Article
- Complementary Strategies to Unlock Biosynthesis Gene Clusters Encoding Secondary Metabolites in the Filamentous FungusJournal of fungi (Basel, Switzerland) · 2022Article
- Recent developments in the biology and biotechnological applications of halotolerant yeasts.World journal of microbiology & biotechnology · 2022Review
- Perturbations of the ileal mycobiota by necrotic enteritis in broiler chickens.Journal of animal science and biotechnology · 2021Article
- Study of the Extremely-Tolerant Brevibacterium linens AE038-8 with Antiviral Activity Against Herpes Simplex Virus Type 1.Current microbiology · 2021Article
- Red algae natural products for prevention of lipopolysaccharides (LPS)-induced liver and kidney inflammation and injuries.Bioscience reports · 2021Article
- Exploring the extremes: applying high concentration of yeast extract leads to drastic morphological changes and elimination of (+)-geodin and asterric acid production in Aspergillus terreus submerged cultures.Biotechnology letters · 2021Article
- Article
- Marine Fungi from the SpongeMarine drugs · 2019Article
- Salinity and Temperature Influence Growth and Pigment Production in the Marine-Derived Fungal StrainMicroorganisms · 2019Article
- Bioguided isolation, characterization and media optimization for production of Lysolipins by actinomycete as antimicrobial compound against Xanthomonas citri subsp. citri.Molecular biology reports · 2018Article
- The GenusMicroorganisms · 2018Review
- Anticancer activities of ethanol extract from the Antarctic freshwater microalga, Botryidiopsidaceae sp.BMC complementary and alternative medicine · 2017Article
- Wallemia peruviensis sp. nov., a new xerophilic fungus from an agricultural setting in South America.Extremophiles : life under extreme conditions · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The food- and airborne fungal genus Wallemia comprises seven xerophilic and halophilic species: W. sebi, W. mellicola, W. canadensis, W. tropicalis, W. muriae, W. hederae and W. ichthyophaga. All listed species are adapted to low water activity and can contaminate food preserved with high amounts of salt or sugar. In relation to food safety, the effect of high salt and sugar concentrations on the production of secondary metabolites by this toxigenic fungus was investigated. The secondary metabolite profiles of 30 strains of the listed species were examined using general growth media, known to support the production of secondary metabolites, supplemented with different concentrations of NaCl, glucose and MgCl2. In more than two hundred extracts approximately one hundred different compounds were detected using high-performance liquid chromatography-diode array detection (HPLC-DAD). Although the genome data analysis of W. mellicola (previously W. sebi sensu lato) and W. ichthyophaga revealed a low number of secondary metabolites clusters, a substantial number of secondary metabolites were detected at different conditions. Machine learning analysis of the obtained dataset showed that NaCl has higher influence on the production of secondary metabolites than other tested solutes. Mass spectrometric analysis of selected extracts revealed that NaCl in the medium affects the production of some compounds with substantial biological activities (wallimidione, walleminol, walleminone, UCA 1064-A and UCA 1064-B). In particular an increase in NaCl concentration from 5% to 15% in the growth media increased the production of the toxic metabolites wallimidione, walleminol and walleminone.
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