ArticlePloS one2016
Dynamic Contrast-Enhanced MRI Perfusion Parameters as Imaging Biomarkers of Angiogenesis.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The microbiome-nitric oxide axis in cancer immunotherapy: a targeted qualitative systematic review of mechanistic and translational evidence.Frontiers in immunology · 2026Pooled it
- Diagnostic performance of kinetic parameters of ultrafast breast MRI and their associations with immunohistopathological findings of breast carcinoma.Scientific reports · 2026Article
- Article
- A deep learning framework to stratify Nottingham histologic grade 2 breast tumors based on dynamic contrast-enhanced MRI.European radiology · 2026Article
- Physics-based simulation of ultrasound propagation from MRI volumes for cross-modal breast imaging.Journal of biological engineering · 2026Article
- MRI-Based Radiomics Model for Classifying Axillary Lymph Node Burden and Disease-Free Survival in Patients With Early-Stage Breast Cancer.Journal of magnetic resonance imaging : JMRI · 2026Article
- Precision Medicine in Orthobiologics: A Paradigm Shift in Regenerative Therapies.Bioengineering (Basel, Switzerland) · 2025Review
- Quantitative dynamic contrast-enhanced MRI parameters effectively predict treatment efficacy of neoadjuvant chemotherapy in breast cancer.American journal of translational research · 2025Article
- Quantitative MR Imaging of the Breast.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Review
- Exploratory Analysis of Radiomics and Pathomics in Uterine Corpus Endometrial Carcinoma.Scientific reports · 2024Article
- Current trends in the characterization and monitoring of vascular response to cancer therapy.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Review
- Galunisertib promotes bevacizumab-induced vascular normalization in nasopharyngeal carcinoma: Multi-parameter MRI evaluation.Molecular therapy. Oncology · 2024Article
- Case Report: Efficacy of Multiparameter MRI in Diagnosis of Chronic Breast Inflammation Complicated with Invasive Ductal Carcinoma and Ductal Carcinoma in situ.Cancer management and research · 2024Article
- Correlation of Perfusion Metrics with Ki-67 Proliferation Index and Axillary Involvement as a Prognostic Marker in Breast Carcinoma Cases: A Dynamic Contrast-Enhanced Perfusion MRI Study.Diagnostics (Basel, Switzerland) · 2023Article
- Identification of triple-negative breast cancer and androgen receptor expression based on histogram and texture analysis of dynamic contrast-enhanced MRI.BMC medical imaging · 2023Article
- Identification of the Benignity and Malignancy of BI-RADS 4 Breast Lesions Based on a Combined Quantitative Model of Dynamic Contrast-Enhanced MRI and Intravoxel Incoherent Motion.Tomography (Ann Arbor, Mich.) · 2022Article
- HyperpolarizedMagnetic resonance in medicine · 2022Review
- New insights into the evaluation of peripheral nerves lesions: a survival guide for beginners.Neuroradiology · 2022Review
- An MRI-Based Clinical-Perfusion Model Predicts Pathological Subtypes of Prevascular Mediastinal Tumors.Diagnostics (Basel, Switzerland) · 2022Article
- Improved value of whole-lesion histogram analysis on DCE parametric maps for diagnosing small breast cancer (≤ 1 cm).European radiology · 2022Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypoxia in the tumor microenvironment is the leading factor in angiogenesis. Angiogenesis can be identified by dynamic contrast-enhanced breast MRI (DCE MRI). Here we investigate the relationship between perfusion parameters on DCE MRI and angiogenic and prognostic factors in patients with invasive ductal carcinoma (IDC). Perfusion parameters (Ktrans, kep and ve) of 81 IDC were obtained using histogram analysis. Twenty-fifth, 50th and 75th percentile values were calculated and were analyzed for association with microvessel density (MVD), vascular endothelial growth factor (VEGF) and conventional prognostic factors. Correlation between MVD and ve50 was positive (r = 0.33). Ktrans50 was higher in tumors larger than 2 cm than in tumors smaller than 2 cm. In multivariate analysis, Ktrans50 was affected by tumor size and MVD with 12.8% explanation. There was significant association between Ktrans50 and tumor size and MVD. Therefore we conclude that DCE MRI perfusion parameters are potential imaging biomarkers for prediction of tumor angiogenesis and aggressiveness.
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