ArticlePLoS computational biology2016
Stability of Cross-Feeding Polymorphisms in Microbial Communities.
Article in PLoS computational biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Initial community composition determines the long-term dynamics of a microbial cross-feeding interaction by modulating niche availability.ISME communications · 2022Article
- The faecal metabolome of black howler monkeys (Alouatta pigra) varies in response to seasonal dietary changes.Molecular ecology · 2022Article
- Xylitol enhances synthesis of propionate in the colon via cross-feeding of gut microbiota.Microbiome · 2021Article
- Extracellular Metabolism Sets the Table for Microbial Cross-Feeding.Microbiology and molecular biology reviews : MMBR · 2021Review
- Evolutionary dynamics and structural consequences of de novo beneficial mutations and mutant lineages arising in a constant environment.BMC biology · 2021Article
- Metabolic modelling approaches for describing and engineering microbial communities.Computational and structural biotechnology journal · 2021Review
- Modeling microbial cross-feeding at intermediate scale portrays community dynamics and species coexistence.PLoS computational biology · 2020Article
- Metabolic multistability and hysteresis in a model aerobe-anaerobe microbiome community.Science advances · 2020Article
- Disruption of cross-feeding interactions by invading taxa can cause invasional meltdown in microbial communities.Proceedings. Biological sciences · 2020Article
- Mutualistic cross-feeding in microbial systems generates bistability via an Allee effect.Scientific reports · 2020Article
- Fitness and Productivity Increase with Ecotypic Diversity amongApplied and environmental microbiology · 2020Article
- Enhanced production of heterologous proteins by a synthetic microbial community: Conditions and trade-offs.PLoS computational biology · 2020Article
- Emerging strategies for engineering microbial communities.Biotechnology advances · 2019Review
- A shared limiting resource leads to competitive exclusion in a cross-feeding system.Environmental microbiology · 2019Article
- A coexistence theory in microbial communities.Royal Society open science · 2018Article
- An enormous potential for niche construction through bacterial cross-feeding in a homogeneous environment.PLoS computational biology · 2018Article
- Article
- Microenvironmental cooperation promotes early spread and bistability of a Warburg-like phenotype.Scientific reports · 2017Article
- Beware batch culture: Seasonality and niche construction predicted to favor bacterial adaptive diversification.PLoS computational biology · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Cross-feeding, a relationship wherein one organism consumes metabolites excreted by another, is a ubiquitous feature of natural and clinically-relevant microbial communities and could be a key factor promoting diversity in extreme and/or nutrient-poor environments. However, it remains unclear how readily cross-feeding interactions form, and therefore our ability to predict their emergence is limited. In this paper we developed a mathematical model parameterized using data from the biochemistry and ecology of an E. coli cross-feeding laboratory system. The model accurately captures short-term dynamics of the two competitors that have been observed empirically and we use it to systematically explore the stability of cross-feeding interactions for a range of environmental conditions. We find that our simple system can display complex dynamics including multi-stable behavior separated by a critical point. Therefore whether cross-feeding interactions form depends on the complex interplay between density and frequency of the competitors as well as on the concentration of resources in the environment. Moreover, we find that subtly different environmental conditions can lead to dramatically different results regarding the establishment of cross-feeding, which could explain the apparently unpredictable between-population differences in experimental outcomes. We argue that mathematical models are essential tools for disentangling the complexities of cross-feeding interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.