Observational studyAmerican journal of respiratory and critical care medicine2017
Shared and Distinct Aspects of the Sepsis Transcriptomic Response to Fecal Peritonitis and Pneumonia.
Observational study in American journal of respiratory and critical care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers, 5 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
142 citing papers in PubMed, 5 syntheses or guidelines pooled it, 248 citations in OpenAlex.
- A consensus blood transcriptomic framework for sepsis.Nature medicine · 2025Guideline
- The Diagnostic Utility of Host RNA Biosignatures in Adult Patients With Sepsis: A Systematic Review and Meta-Analysis.Critical care explorations · 2025Pooled it
- Upregulation of CRISP3 and its clinical values in adult sepsis: a comprehensive analysis based on microarrays and a two-retrospective-cohort study.Frontiers in immunology · 2024Pooled it
- Pooled prevalence of lymphopenia in all-cause hospitalisations and association with infection: a systematic review and meta-analysis.BMC infectious diseases · 2023Pooled it
- The immunosuppressive face of sepsis early on intensive care unit-A large-scale microarray meta-analysis.PloS one · 2018Pooled it
- Molecular pathways driving clarithromycin benefit in community-acquired pneumonia: analysis of the ACCESS randomised trial.EBioMedicine · 2026Trial
- Transcriptomic Signatures in Sepsis and a Differential Response to Steroids. From the VANISH Randomized Trial.American journal of respiratory and critical care medicine · 2019Trial
- Treatment With Acetylsalicylic Acid Reverses Endotoxin Tolerance in Humans In Vivo: A Randomized Placebo-Controlled Study.Critical care medicine · 2019Trial
- Discordant Interleukin-27 (IL-27) Subunit Transcription in Human Sepsis Exposes a Molecular-Attribution Gap.Biomedicines · 2026Article
- An NLRP3 inflammasome-anchored Astragalus mechanistic prior yields a mortality-associated transcriptomic signal in ICU sepsis: a secondary analysis with exploratory cross-cohort assessment.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Longitudinal blood transcriptome profiling reveals immune dynamics in sepsis.BMC infectious diseases · 2026Article
- Neutrophil Transcriptomic Changes in Severe Sterile Vasoplegic Syndrome Resemble a Distinct Molecular Subtype of Septic Shock.Shock (Augusta, Ga.) · 2026Article
- Context-specific regulatory genetic variation in MTOR dampens neutrophil-T cell crosstalk in pneumonia-associated sepsis.Nature communications · 2026Article
- Real-world longitudinal validation of high-income-country-derived sepsis endotypes in sub-Saharan Africa: a nested prospective multicenter study.Critical care (London, England) · 2026Article
- Artificial intelligence for sepsis management in the emergency department.BMC infectious diseases · 2026Review
- Identification of immune status subtypes and prognostic analysis of septic patients based on Th1/Th2 cytokine assays.Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- Single-cell multi-omic landscape reveals anatomical-specific immune features in adult and pediatric sepsis.Nature immunology · 2026Article
- Construction of a sepsis recovery-failure axis and single-cell anchoring using public multi-cohort whole-blood and single-cell transcriptomic data.Frontiers in medicine · 2026Article
- Clinical subphenotypes and molecular endotypes in sepsis: toward an integrated and dynamic framework.Annals of intensive care · 2026Review
- An 11-gene blood transcriptomic signature reflects a sepsis-associated host-response pattern across public cohorts.Frontiers in medicine · 2026Article
82 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
rationaleHeterogeneity in the septic response has hindered efforts to understand pathophysiology and develop targeted therapies. Source of infection, with different causative organisms and temporal changes, might influence this heterogeneity.
objectivesTo investigate individual and temporal variations in the transcriptomic response to sepsis due to fecal peritonitis, and to compare these with the same parameters in community-acquired pneumonia.
methodsWe performed genome-wide gene expression profiling in peripheral blood leukocytes of adult patients admitted to intensive care with sepsis due to fecal peritonitis (n = 117) or community-acquired pneumonia (n = 126), and of control subjects without sepsis (n = 10). MEASUREMENTS AND MAIN
resultsA substantial portion of the transcribed genome (18%) was differentially expressed compared with that of control subjects, independent of source of infection, with eukaryotic initiation factor 2 signaling being the most enriched canonical pathway. We identified two sepsis response signature (SRS) subgroups in fecal peritonitis associated with early mortality (P = 0.01; hazard ratio, 4.78). We defined gene sets predictive of SRS group, and serial sampling demonstrated that subgroup membership is dynamic during intensive care unit admission. We found that SRS is the major predictor of transcriptomic variation; a small number of genes (n = 263) were differentially regulated according to the source of infection, enriched for IFN signaling and antigen presentation. We define temporal changes in gene expression from disease onset involving phagosome formation as well as natural killer cell and IL-3 signaling.
conclusionsThe majority of the sepsis transcriptomic response is independent of the source of infection and includes signatures reflecting immune response state and prognosis. A modest number of genes show evidence of specificity. Our findings highlight opportunities for patient stratification and precision medicine in sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.