ArticleACS applied materials & interfaces2017
Low-Initial-Modulus Biodegradable Polyurethane Elastomers for Soft Tissue Regeneration.
Article in ACS applied materials & interfaces, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 84 citations in OpenAlex.
- A Multifunctional Mesoporous Janus Separator With Optimized Mass Transport Regulation Enabling 800-Cycle Lithium-Oxygen Batteries.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Programmable Handheld Extrusion-Based Bioprinting Platform for In Situ Skin Wounds Dressing: Balance Mobility and Customizability.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Article
- Reduced Graphene-Oxide-Doped Elastic Biodegradable Polyurethane Fibers for Cardiomyocyte Maturation.ACS biomaterials science & engineering · 2024Article
- Remodeling of the Intra-Conduit Inflammatory Microenvironment to Improve Peripheral Nerve Regeneration with a Neuromechanical Matching Protein-Based Conduit.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Synthesizing Polyurethane Using Isosorbide in Primary Alcohol Form, and Its Biocompatibility Properties.Polymers · 2023Article
- Polyurethane-PRSC advances · 2022Article
- Rational design of biodegradable thermoplastic polyurethanes for tissue repair.Bioactive materials · 2022Review
- Review
- High ion conductivity based on a polyurethane composite solid electrolyte for all-solid-state lithium batteries.RSC advances · 2022Article
- A Review of Biomaterials and Scaffold Fabrication for Organ-on-a-Chip (OOAC) Systems.Bioengineering (Basel, Switzerland) · 2021Review
- Fast photocurable thiol-ene elastomers with tunable biodegradability, mechanical and surface properties enhance myoblast differentiation and contractile function.Bioactive materials · 2021Article
- Biobased polyurethanes for biomedical applications.Bioactive materials · 2021Review
- Optimizing Anisotropic Polyurethane Scaffolds to Mechanically Match with Native Myocardium.ACS biomaterials science & engineering · 2020Article
- Current advances in biodegradable synthetic polymer based cardiac patches.Journal of biomedical materials research. Part A · 2020Review
- Fabrication and Properties of a Bio-Based Biodegradable Thermoplastic Polyurethane Elastomer.Polymers · 2019Article
- Preparation and Characterization of Poly(δ-Valerolactone)/TiOMaterials (Basel, Switzerland) · 2019Article
- Enhancing anti-thrombogenicity of biodegradable polyurethanes through drug molecule incorporation.Journal of materials chemistry. B · 2018Article
- Article
- Highly Elastic Biodegradable Single-Network Hydrogel for Cell Printing.ACS applied materials & interfaces · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The mechanical match between synthetic scaffold and host tissue remains challenging in tissue regeneration. The elastic soft tissues exhibit low initial moduli with a J-shaped tensile curve. Suitable synthetic polymer scaffolds require low initial modulus and elasticity. To achieve these requirements, random copolymers poly(δ-valerolactone-co-ε-caprolactone) (PVCL) and hydrophilic poly(ethylene glycol) (PEG) were combined into a triblock copolymer, PVCL-PEG-PVCL, which was used as a soft segment to synthesize a family of biodegradable elastomeric polyurethanes (PU) with low initial moduli. The triblock copolymers were varied in chemical components, molecular weights, and hydrophilicities. The mechanical properties of polyurethanes in dry and wet states can be tuned by altering the molecular weights and hydrophilicities of the soft segments. Increasing the length of either PVCL or PEG in the soft segments reduced initial moduli of the polyurethane films and scaffolds in dry and wet states. The polymer films are found to have good cell compatibility and to support fibroblast growth in vitro. Selected polyurethanes were processed into porous scaffolds by a thermally induced phase-separation technique. The scaffold from PU-PEG
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.