ReviewInternational journal of molecular sciences2016
Current Concepts of ARDS: A Narrative Review.
Review in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04472260 (Early Verticalization of the Patient With Acute Respiratory Distress Syndrome), which is not on this map. Cited by 64 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Verticalization of the Patient With Acute Respiratory Distress Syndrome: Assessment of Feasibility and Safety.
Who cites it
64 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Circulating Pulmonary-Originated Epithelial Biomarkers for Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2023Pooled it
- The effect of diabetes on the risk and mortality of acute lung injury/acute respiratory distress syndrome: A meta-analysis.Medicine · 2019Pooled it
- The Effect of Alcohol Consumption on the Risk of ARDS: A Systematic Review and Meta-Analysis.Chest · 2018Pooled it
- Mechanistic Insights into Pulmonary Surfactant Inactivation.Langmuir : the ACS journal of surfaces and colloids · 2026Article
- Evaluation of the protective effect of direct peritoneal resuscitation on lung injury in a controlled hemorrhagic shock model in rats.Scientific reports · 2026Article
- A multilevel analysis of mortality and determinants among patients with acute respiratory distress syndrome in Ethiopia.Scientific reports · 2026Observational
- Severe acute respiratory distress syndrome following laparoscopic appendectomy in a previously healthy middle-aged man: A case report.The Journal of international medical research · 2026Article
- NLRP3 inflammasomes at the ARDS-cancer interface: mechanisms and translational hypotheses.Frontiers in immunology · 2026Review
- Cytosolic nucleic acid sensing as driver of critical illness: mechanisms and advances in therapy.Signal transduction and targeted therapy · 2025Review
- Integrated mRNA-miRNA transcriptome profiling of blood immune responses potentially related to pulmonary fibrosis in forest musk deer.Frontiers in immunology · 2024Article
- Role of DCLK1/Hippo pathway in type II alveolar epithelial cells differentiation in acute respiratory distress syndrome.Molecular medicine (Cambridge, Mass.) · 2023Article
- Toxicologic pathological mechanism of acute lung injury induced by oral administration of benzalkonium chloride in mice.Toxicological research · 2023Article
- The Promise of Continuous Kidney Replacement Therapy Optimization to Improve Patient Outcomes and Reduce Resource Utilization.Kidney medicine · 2023Article
- Genetic Determinants of the Acute Respiratory Distress Syndrome.Journal of clinical medicine · 2023Review
- Acute respiratory distress syndrome enhances tumor metastasis into lungs: Role of BRD4 in the tumor microenvironment.International immunopharmacology · 2023Article
- Macrophage-Targeted Nanomedicines for ARDS/ALI: Promise and Potential.Inflammation · 2022Review
- Transcriptome profiling of lung immune responses potentially related to acute respiratory distress syndrome in forest musk deer.BMC genomics · 2022Article
- Acute respiratory distress syndrome due to sepsis caused by Bacteroides ovatus after acute appendicectomy.Surgical case reports · 2022Article
- MicroRNA-155-5p modulates the progression of acute respiratory distress syndrome by targeting interleukin receptors.Bioengineered · 2022Article
- Levosimendan Ameliorates Cardiopulmonary Function but Not Inflammatory Response in a Dual Model of Experimental ARDS.Biomedicines · 2022Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute respiratory distress syndrome (ARDS) is characterized by the acute onset of pulmonary edema of non-cardiogenic origin, along with bilateral pulmonary infiltrates and reduction in respiratory system compliance. The hallmark of the syndrome is refractory hypoxemia. Despite its first description dates back in the late 1970s, a new definition has recently been proposed. However, the definition remains based on clinical characteristic. In the present review, the diagnostic workup and the pathophysiology of the syndrome will be presented. Therapeutic approaches to ARDS, including lung protective ventilation, prone positioning, neuromuscular blockade, inhaled vasodilators, corticosteroids and recruitment manoeuvres will be reviewed. We will underline how a holistic framework of respiratory and hemodynamic support should be provided to patients with ARDS, aiming to ensure adequate gas exchange by promoting lung recruitment while minimizing the risk of ventilator-induced lung injury. To do so, lung recruitability should be considered, as well as the avoidance of lung overstress by monitoring transpulmonary pressure or airway driving pressure. In the most severe cases, neuromuscular blockade, prone positioning, and extra-corporeal life support (alone or in combination) should be taken into account.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.