ArticleNutrients2016
Effects of Supplementation of Branched-Chain Amino Acids to Reduced-Protein Diet on Skeletal Muscle Protein Synthesis and Degradation in the Fed and Fasted States in a Piglet Model.
Article in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Protective Effect of Amino Acids on the Muscle Injury of Aerobics Athletes after Endurance Exercise Based on CT Images.Journal of healthcare engineering · 2022Trial
- Carbohydrate and protein adaptation in low-protein diets for livestock and poultry: a nutritional revolution from static balance to dynamic synergy.Journal of animal science and biotechnology · 2026Review
- Targeted delivery of curcumin based on nanocarriers: potential therapeutic strategies for noninfectious arthritis.Inflammopharmacology · 2026Review
- Article
- Proline-driven metabolic reprogramming promotes skeletal muscle hypertrophy and oxidative myofiber specification in porcine offspring: a stage-optimized maternal nutritional intervention.Journal of animal science and biotechnology · 2025Article
- The composition of branched-chain amino acids modulates response to nucleotide supplementation of low-protein diets in nursery pigs.Journal of animal science · 2025Article
- Effect of a low-protein diet during mid-to-late gestation on reproductive performance and serum amino acid profiles in sows.Journal of animal science · 2025Article
- The biological functions and metabolic pathways of valine in swine.Journal of animal science and biotechnology · 2023Review
- Potential Influence of Exercise-Induced Rhabdomyolysis by Branched-Chain Amino Acid Supplementation.Iranian journal of public health · 2022Article
- Submaximal Force Steadiness and Accuracy in Patients With Chronic Ankle Instability.Journal of athletic training · 2021Article
- Dietary isoleucine improved flesh quality, muscle antioxidant capacity, and muscle growth associated with AKT/TOR/S6K1 and AKT/FOXO3a signaling in hybrid bagrid catfish (Pelteobagrus vachelli♀ × Leiocassis longirostris♂).Journal of animal science and biotechnology · 2021Article
- Fermented Feed Modulates Meat Quality and Promotes the Growth ofAnimals : an open access journal from MDPI · 2020Article
- Differential Metabolomics Profiles Identified by CE-TOFMS between High and Low Intramuscular Fat Amount in Fattening Pigs.Metabolites · 2020Article
- Metabolomic Profiling Revealed Potential Biomarkers in Patients With Moyamoya Disease.Frontiers in neuroscience · 2020Article
- Binding Characteristics and Superimposed Antioxidant Properties of Caffeine Combined with Superoxide Dismutase.ACS omega · 2019Article
- Keto-Adaptation and Endurance Exercise Capacity, Fatigue Recovery, and Exercise-Induced Muscle and Organ Damage Prevention: A Narrative Review.Sports (Basel, Switzerland) · 2019Review
- Advances in low-protein diets for swine.Journal of animal science and biotechnology · 2018Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Supplementation of branched-chain amino acids (BCAA) has been demonstrated to promote skeletal muscle mass gain, but the mechanisms underlying this observation are still unknown. Since the regulation of muscle mass depends on a dynamic equilibrium (fasted losses-fed gains) in protein turnover, the aim of this study was to investigate the effects of BCAA supplementation on muscle protein synthesis and degradation in fed/fasted states and the related mechanisms. Fourteen 26- (Experiment 1) and 28-day-old (Experiment 2) piglets were fed reduced-protein diets without or with supplemental BCAA. After a four-week acclimation period, skeletal muscle mass and components of anabolic and catabolic signaling in muscle samples after overnight fasting were determined in Experiment 1. Pigs in Experiment 2 were implanted with carotid arterial, jugular venous, femoral arterial and venous catheters, and fed once hourly along with the intravenous infusion of NaH
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.