Evidence map›Paper›PMID 28035974›Full record

ArticleToxins2016

A Novel Toxin from Haplopelma lividum Selectively Inhibits the Na

Ping Meng, Honggang Huang, Gan Wang, Shilong Yang, Qiuming Lu, Jingze Liu, Ren Lai, Mingqiang Rong

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

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  12. Pain-related toxins in scorpion and spider venoms: a face to face with ion channels.The journal of venomous animals and toxins including tropical diseases · 2021
    Review
  13. Article
  14. Article
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  17. Sodium channels and pain: from toxins to therapies.British journal of pharmacology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Ping MengKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China. mengping@mail.kiz.ac.cn.
Honggang HuangDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense 6550 1000, Denmark. hhuang@bmb.sdu.dk.
Gan WangLife Sciences College, Nanjing Agricultural University, Nanjing 210095, Jiangsu, China. wang.gan@outlook.com.
Shilong YangKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China. yslzoology@163.com.
Qiuming LuKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China. lvqm@mail.kiz.ac.cn.
Jingze LiuKey Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, College of Life Sciences, Hebei Normal University, Shijiazhuang 050024, Hebei, China. jzliu21@heinfo.net.
Ren LaiKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China. rlai@mail.kiz.ac.cn.
Mingqiang RongKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China. rongmingqiang@mail.kiz.ac.cn.
Kunming Institute of Zoology · CNDanish Diabetes Academy · DKHebei Normal University · CNNanjing Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spider venoms are a complex mixture of peptides with a large number of neurotoxins targeting ion channels. Although thousands of peptide toxins have been identified from venoms of numerous species of spiders, many unknown species urgently need to be investigated. In this study, a novel sodium channel inhibitor, µ-TRTX-Hl1a, was identified from the venom of

Indexed as

SpidersAmino Acid SequenceAnalgesicsAnimalsBase SequenceCell LineHEK293 CellsHumansMiceMorphineNAV1.8 Voltage-Gated Sodium ChannelNeuralgiaSequence Analysis, DNASpider VenomsVoltage-Gated Sodium Channel BlockersAnalgesicsMorphineNAV1.8 Voltage-Gated Sodium ChannelSpider VenomsVoltage-Gated Sodium Channel BlockersanalgesiaNaV1.8neurotoxinspidervenom

Identifiers

PMID28035974
PMCPMC5308240
OpenAlexW2566627348

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.