ArticleHuman brain mapping2017
Reduced perfusion in Broca's area in developmental stuttering.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Hand Preference in Stuttering: Meta-Analyses.Neuropsychology review · 2024Pooled it
- Exploring Photobiomodulation as a Potential Novel Intervention for Developmental Stuttering: A Review and Hypothesis.Journal of clinical medicine · 2026Review
- The effects of transcranial direct current stimulation and fluency shaping techniques on enhancing speech fluency in adults who stutter: Protocol for a double-blind randomized controlled trial.Contemporary clinical trials communications · 2025Article
- Auditory Processing in Stuttering Children: Behavioral and Electrophysiological Assessments.International archives of otorhinolaryngology · 2025Article
- Abnormal cerebral blood flow in children with developmental stuttering.Pediatric research · 2024Article
- Hypertensive disorders of pregnancy, neonatal outcomes and offspring developmental delay in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Psychedelics in developmental stuttering to modulate brain functioning: a new therapeutic perspective?Frontiers in human neuroscience · 2024Article
- Dissecting structural connectivity of the left and right inferior frontal cortex in children who stutter.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- A comparison of structural morphometry in children and adults with persistent developmental stuttering.Brain communications · 2023Article
- Atypical development of Broca's area in a large family with inherited stuttering.Brain : a journal of neurology · 2022Article
- Epilepsy and Diagnostic Dilemmas: The Role of Language and Speech-Related Seizures.Journal of personalized medicine · 2022Review
- rsfMRI based evidence for functional connectivity alterations in adults with developmental stuttering.Heliyon · 2021Article
- Association Between Gray Matter Volume Variations and Energy Utilization in the Brain: Implications for Developmental Stuttering.Journal of speech, language, and hearing research : JSLHR · 2021Article
- Use of random matrix theory in the discovery of resting state brain networks.Magnetic resonance imaging · 2021Article
- Stuttering: A Disorder of Energy Supply to Neurons?Frontiers in human neuroscience · 2021Article
- Speech Fluency Improvement in Developmental Stuttering Using Non-invasive Brain Stimulation: Insights From Available Evidence.Frontiers in human neuroscience · 2021Review
- Functional and Neuroanatomical Bases of Developmental Stuttering: Current Insights.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2019Review
- Anomalous morphology in left hemisphere motor and premotor cortex of children who stutter.Brain : a journal of neurology · 2018Article
- Cluster-level statistical inference in fMRI datasets: The unexpected behavior of random fields in high dimensions.Magnetic resonance imaging · 2018Article
- White matter developmental trajectories associated with persistence and recovery of childhood stuttering.Human brain mapping · 2017Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveTo study resting cerebral blood flow in children and adults with developmental stuttering.
methodsWe acquired pulsed arterial spin labeling magnetic resonance imaging data in 26 participants with stuttering and 36 healthy, fluent controls. While covarying for age, sex, and IQ, we compared perfusion values voxel-wise across diagnostic groups and assessed correlations of perfusion with stuttering severity within the stuttering group and with measures of motor speed in both groups.
resultsWe detected lower regional Cerebral Blood Flow (rCBF) at rest in the stuttering group compared with healthy controls in Broca's area bilaterally and the superior frontal gyrus. rCBF values in Broca's area bilaterally correlated inversely with the severity of stuttering and extended posteriorly into other portions of the language loop. We also found increased rCBF in cerebellar nuclei and parietal cortex in the stuttering group compared with healthy controls. Findings were unchanged in child-only analyses and when excluding participants with comorbid illnesses or those taking medication.
conclusionsrCBF is reduced in Broca's region in persons who stutter. More severe stuttering is associated with even greater reductions in rCBF to Broca's region, additive to the underlying putative trait reduction in rCBF relative to control values. Moreover, a greater abnormality in rCBF in the posterior language loop is associated with more severe symptoms, suggesting that a common pathophysiology throughout the language loop likely contributes to stuttering severity. Hum Brain Mapp 38:1865-1874, 2017. © 2017 Wiley Periodicals, Inc.
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