ArticleJournal of microbiology (Seoul, Korea)2017
Biosynthesis and uptake of glycine betaine as cold-stress response to low temperature in fish pathogen Vibrio anguillarum.
Article in Journal of microbiology (Seoul, Korea), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Inhibitory effects of esculetin as a quorum sensing inhibitor on biofilm formation and virulence factors in Vibrio anguillarum.World journal of microbiology & biotechnology · 2026Article
- A hidden pattern? Common polyextremophilic microbial adaptations in Icy Moon analog environments.Frontiers in astronomy and space sciences · 2026Article
- Untargeted Metabolomics Reveals Seasonal and Tissue-Specific Metabolic Shifts in Holothuria cinerascens.Chemistry & biodiversity · 2026Article
- Article
- Transcriptomic profiling ofMicrobial genomics · 2025Article
- Investigation of different cold adaptation abilities in Salmonella enterica serotype Typhimurium strains using extracellular metabolomic approach.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Metabolomic profiling ofComputational and structural biotechnology journal · 2025Article
- Seasonal Mortality of Wild Atlantic Menhaden (Transboundary and emerging diseases · 2024Article
- A general overview of the multifactorial adaptation to cold: biochemical mechanisms and strategies.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Review
- Shift of Choline/Betaine Pathway in RecombinantInternational journal of molecular sciences · 2022Article
- The cold adaption profiles ofBiotechnology reports (Amsterdam, Netherlands) · 2021Article
- Article
- The Temperature-Dependent Expression of the High-Pathogenicity Island Encoding Piscibactin inFrontiers in microbiology · 2021Article
- Stressed out: Bacterial response to high salinity using compatible solute biosynthesis and uptake systems, lessons fromComputational and structural biotechnology journal · 2021Review
- Choline-betaine pathway contributes to hyperosmotic stress and subsequent lethal stress resistance inJournal of biosciences · 2020Article
- The Expression of Virulence Factors inFrontiers in microbiology · 2019Article
- Article
- Changes in Transcriptome ofFrontiers in cellular and infection microbiology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fish pathogen Vibrio anguillarum, a mesophile bacterium, is usually found in estuarine and marine coastal ecosystems worldwide that pose a constant stress to local organism by its fluctuation in salinity as well as notable temperature change. Though V. anguillarum is able to proliferate while maintain its pathogenicity under low temperature (5-18°C), so far, coldadaption molecular mechanism of the bacteria is unknown. In this study, V. anguillarum was found possessing a putative glycine betaine synthesis system, which is encoded by betABI and synthesizes glycine betaine from its precursor choline. Furthermore, significant up-regulation of the bet gene at the transcriptional level was noted in log phase in response to cold-stress. Moreover, the accumulation of betaine glycine was only found appearing at low growth temperatures, suggesting that response regulation of both synthesis system and transporter system are cold-dependent. Furthermore, in-frame deletion mutation in the two putative ABC transporters and three putative BCCT family transporters associated with glycine betaine uptake could not block cellular accumulation of betaine glycine in V. anguillarum under coldstress, suggesting the redundant feature in V. anguillarum betaine transporter system. These findings confirmed that glycine betaine serves as an effective cold stress protectant and highlighted an underappreciated facet of the acclimatization of V. anguillarum to cold environments.
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