ReviewAdvances in experimental medicine and biology2016
Toward a Proprioceptive Neural Interface that Mimics Natural Cortical Activity.
Review in Advances in experimental medicine and biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Towards neuromorphic neurotechnologies: integrating brain-inspired computing with brain-computer interfaces.npj biomedical innovations · 2026Review
- Integration of learned artificial sensation with vision during freely moving navigation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Predicting proprioceptive cortical anatomy and neural coding with topographic autoencoders.PLoS computational biology · 2024Article
- Biomimetic computer-to-brain communication enhancing naturalistic touch sensations via peripheral nerve stimulation.Nature communications · 2024Article
- Neurosurgery and the Brain-Computer Interface.Advances in experimental medicine and biology · 2024Review
- Amplitude- and frequency-dependent activation of layer II/III neurons by intracortical microstimulation.iScience · 2023Article
- Restoration of sensory information via bionic hands.Nature biomedical engineering · 2023Review
- Symbiotic electroneural and musculoskeletal framework to encode proprioception via neurostimulation: ProprioStim.iScience · 2023Article
- Review
- Characterizing the short-latency evoked response to intracortical microstimulation across a multi-electrode array.Journal of neural engineering · 2022Article
- The science and engineering behind sensitized brain-controlled bionic hands.Physiological reviews · 2022Review
- Intrinsic somatosensory feedback supports motor control and learning to operate artificial body parts.Journal of neural engineering · 2022Article
- Charge injection characteristics of sputtered ruthenium oxide electrodes for neural stimulation and recording.Journal of biomedical materials research. Part B, Applied biomaterials · 2022Article
- Sputtered ruthenium oxide coatings for neural stimulation and recording electrodes.Journal of biomedical materials research. Part B, Applied biomaterials · 2021Article
- A comprehensive model-based framework for optimal design of biomimetic patterns of electrical stimulation for prosthetic sensation.Journal of neural engineering · 2020Article
- Decoding hand kinematics from population responses in sensorimotor cortex during grasping.Journal of neural engineering · 2020Article
- The combination of brain-computer interfaces and artificial intelligence: applications and challenges.Annals of translational medicine · 2020Review
- Article
- Longitudinal multimodal assessment of neurodegeneration and vascular remodeling correlated with signal degradation in chronic cortical silicon microelectrodes.Neurophotonics · 2020Article
- Short reaction times in response to multi-electrode intracortical microstimulation may provide a basis for rapid movement-related feedback.Journal of neural engineering · 2019Article
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Authors and funding
2 authors.
Funding
Abstract
The dramatic advances in efferent neural interfaces over the past decade are remarkable, with cortical signals used to allow paralyzed patients to control the movement of a prosthetic limb or even their own hand. However, this success has thrown into relief, the relative lack of progress in our ability to restore somatosensation to these same patients. Somatosensation, including proprioception, the sense of limb position and movement, plays a crucial role in even basic motor tasks like reaching and walking. Its loss results in crippling deficits. Historical work dating back decades and even centuries has demonstrated that modality-specific sensations can be elicited by activating the central nervous system electrically. Recent work has focused on the challenge of refining these sensations by stimulating the somatosensory cortex (S1) directly. Animals are able to detect particular patterns of stimulation and even associate those patterns with particular sensory cues. Most of this work has involved areas of the somatosensory cortex that mediate the sense of touch. Very little corresponding work has been done for proprioception. Here we describe the effort to develop afferent neural interfaces through spatiotemporally precise intracortical microstimulation (ICMS). We review what is known of the cortical representation of proprioception, and describe recent work in our lab that demonstrates for the first time, that sensations like those of natural proprioception may be evoked by ICMS in S1. These preliminary findings are an important first step to the development of an afferent cortical interface to restore proprioception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.