Evidence map›Paper›PMID 28035201›Full record

ArticleGastroenterology & hepatology2016

The Role of Biosimilars in Inflammatory Bowel Disease.

Sudarshan Paramsothy, Noa Krugliak Cleveland, Nada Zmeter, David T Rubin

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Gastroenterology & hepatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sudarshan ParamsothyDr Paramsothy is an advanced IBD fellow, Dr Krugliak Cleveland is an internal medicine resident, Dr Zmeter is a clinical research coordinator, and Dr Rubin is a professor of medicine at the Inflammatory Bowel Disease Center at the University of Chicago Medicine in Chicago, Illinois.
Noa Krugliak ClevelandDr Paramsothy is an advanced IBD fellow, Dr Krugliak Cleveland is an internal medicine resident, Dr Zmeter is a clinical research coordinator, and Dr Rubin is a professor of medicine at the Inflammatory Bowel Disease Center at the University of Chicago Medicine in Chicago, Illinois.
Nada ZmeterDr Paramsothy is an advanced IBD fellow, Dr Krugliak Cleveland is an internal medicine resident, Dr Zmeter is a clinical research coordinator, and Dr Rubin is a professor of medicine at the Inflammatory Bowel Disease Center at the University of Chicago Medicine in Chicago, Illinois.
David T RubinDr Paramsothy is an advanced IBD fellow, Dr Krugliak Cleveland is an internal medicine resident, Dr Zmeter is a clinical research coordinator, and Dr Rubin is a professor of medicine at the Inflammatory Bowel Disease Center at the University of Chicago Medicine in Chicago, Illinois.
University of Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monoclonal antibody biologic therapies, introduced nearly 20 years ago, revolutionized the treatment of inflammatory bowel disease (IBD) and are now well established as the most effective agents available. As the first of these biologic agents starts to come off patent, biosimilar agents have emerged as alternatives to originator drugs. The unique drug development and manufacturing processes involved in the creation of biologic agents pose distinct regulatory challenges compared to generic formulations of conventional medications. Reductions in medication costs have been proposed to be a major benefit of biosimilar therapies; however, there are concerns regarding the adequacy of the existing regulatory process and data requirements for biosimilar therapy approval, as well as the true bioequivalence of these agents. Infliximab biosimilars for the treatment of IBD have been available in Europe and Asia for a few years and are expected to become available in the United States within the next 1 to 2 years. This article reviews biosimilar therapies and the current data with respect to IBD.

Indexed as

biologicBiosimilarCrohn’s diseaseinflammatory bowel diseaseulcerative colitis

Identifiers

PMID28035201
PMCPMC5193082
OpenAlexW2969537829

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.