ArticleExperimental neurobiology2016
Bipolar Disorder Associated microRNA, miR-1908-5p, Regulates the Expression of Genes Functioning in Neuronal Glutamatergic Synapses.
Article in Experimental neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Bioinformatics Analysis Reveals the Role of DLGAP4 in the Development and Progression of Hepatocellular Carcinoma.Journal of gastrointestinal cancer · 2025Article
- Integrative analysis of miRNA expression profiles reveals distinct and common molecular mechanisms underlying broad diagnostic groups of severe mental disorders.Molecular psychiatry · 2025Article
- Epigenetics and Gut Microbiota in the Pathogenesis and Treatment of Bipolar Disorder (BD).Cells · 2025Review
- Glutamate metabotropic receptor 4 in breast cancer: a potential and specific target for chimeric antigen receptor therapy.Frontiers in oncology · 2025Article
- Mapping microRNA expression quantitative trait loci in the prenatal human brain implicates miR-1908-5p expression in bipolar disorder and other brain-related traits.Human molecular genetics · 2023Article
- Review
- miR-1908: a microRNA with diverse functions in cancers and non-malignant conditions.Cancer cell international · 2022Review
- miR-1908 Dysregulation in Human Cancers.Frontiers in oncology · 2022Review
- Phosphoproteomic profiling of the hippocampus of offspring rats exposed to prenatal stress.Brain and behavior · 2021Article
- A Comprehensive Review on the Role of Non-Coding RNAs in the Pathophysiology of Bipolar Disorder.International journal of molecular sciences · 2021Review
- miR760 regulates ATXN1 levels via interaction with its 5' untranslated region.Genes & development · 2020Article
- MicroRNA Alterations in Induced Pluripotent Stem Cell-Derived Neurons from Bipolar Disorder Patients: Pathways Involved in Neuronal Differentiation, Axon Guidance, and Plasticity.Stem cells and development · 2020Article
- Changes in Non-Coding RNA in Depression and Bipolar Disorder: Can They Be Used as Diagnostic or Theranostic Biomarkers?Non-coding RNA · 2020Review
- MicroRNA sequencing of rat hippocampus and human biofluids identifies acute, chronic, focal and diffuse traumatic brain injuries.Scientific reports · 2020Article
- Functional Analysis of the 3' Untranslated Region of the HumanNeuropsychiatric disease and treatment · 2020Article
- Transcriptome analyses suggest minimal effects of Shank3 dosage on directional gene expression changes in the mouse striatum.Animal cells and systems · 2019Article
- Unexpected Compensatory Increase inFrontiers in molecular neuroscience · 2019Article
- Epigenetic regulation of melatonin receptors in neuropsychiatric disorders.British journal of pharmacology · 2018Review
- Dysregulation of miRNA and its potential therapeutic application in schizophrenia.CNS neuroscience & therapeutics · 2018Review
- Adipose depot-specific effects of ileal interposition surgery in UCD-T2D rats: unexpected implications for obesity and diabetes.The Biochemical journal · 2018Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bipolar disorder (BD), characterized by recurrent mood swings between depression and mania, is a highly heritable and devastating mental illness with poorly defined pathophysiology. Recent genome-wide molecular genetic studies have identified several protein-coding genes and microRNAs (miRNAs) significantly associated with BD. Notably, some of the proteins expressed from BD-associated genes function in neuronal synapses, suggesting that abnormalities in synaptic function could be one of the key pathogenic mechanisms of BD. In contrast, however, the role of BD-associated miRNAs in disease pathogenesis remains largely unknown, mainly because of a lack of understanding about their target mRNAs and pathways in neurons. To address this problem, in this study, we focused on a recently identified BD-associated but uncharacterized miRNA, miR-1908-5p. We identified and validated its novel target genes including
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.