Evidence map›Paper›PMID 28034993›Full record

ArticleHaematologica2017

Lenalidomide combined with intensive chemotherapy in acute myeloid leukemia and higher-risk myelodysplastic syndrome with 5q deletion. Results of a phase II study by the

Lionel Ades, Thomas Prebet, Aspasia Stamatoullas, Christian Recher, Romain Guieze, Emmanuel Raffoux, Krimo Bouabdallah, Mathilde Hunault, Eric Wattel, Laure Stalnikiewicz and 8 more

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 10 institutions in 1 country.

Lionel AdesHôpital St Louis, Assistance Publique-Hôpitaux de Paris and Paris 7 University, Paris, France.
Thomas PrebetInstitut Paoli-Calmettes, Marseille, France.
Aspasia StamatoullasService d'Hématologie, Rouen, France.
Christian RecherHématologie, CHU de Toulouse, France.
Romain GuiezeService d'Hématologie, Clermont-Ferrand, France.
Emmanuel RaffouxHôpital Saint Louis, Paris, France.
Krimo BouabdallahService d'Hématologie Clinique et de Thérapie Cellulaire, CHU de Bordeaux Hôpital du Haut-Lévêque, Pessac, France.
Mathilde HunaultService d'Hématologie, Angers, France.
Eric WattelService d'Hématologie, Lyon, France.
Laure StalnikiewiczService d'Hématologie, Lens, France.
Andrea TomaHôpital Henri Mondor, Créteil, France.
Hervé DombretHôpital Saint Louis, Paris, France.
Norbert VeyInstitut Paoli-Calmettes, Marseille, France.
Marie SebertHôpital St Louis, Assistance Publique-Hôpitaux de Paris and Paris 7 University, Paris, France.
Claude GardinHopital Avicenne and Paris 13 University, France.
Cendrine ChaffautSBIM, Hôpital Saint Louis, Paris, France.
Sylvie ChevretSBIM, Hôpital Saint Louis, Paris, France.
Pierre FenauxHôpital St Louis, Assistance Publique-Hôpitaux de Paris and Paris 7 University, Paris, France pierre.fenaux@aphp.fr.
Hôpital Saint-Louis · FRAssistance Publique – Hôpitaux de Paris · FRInstitut Paoli-Calmettes · FRCentre Hospitalier de Lens · FRCentre Hospitalier Universitaire d'Angers · FRCentre Hospitalier Universitaire de Bordeaux · FRCentre Hospitalier Universitaire de Clermont-Ferrand · FRCentre Hospitalier Universitaire de Toulouse · FRUniversité Paris Cité · FRUniversité Sorbonne Paris Nord · FR

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Patients with acute myeloblastic leukemia or higher risk myelodysplastic syndromes with 5q deletion (generally within a complex karyotype) respond poorly to intensive chemotherapy and have very poor survival. In this population, we evaluated escalating doses of lenalidomide combined with intensive chemotherapy in a phase II study. Treatment consisted of daunorubicin (45 mg/m

Indexed as

Chromosome DeletionChromosomes, Human, Pair 5AdultAgedAntineoplastic Combined Chemotherapy ProtocolsFemaleHumansLenalidomideLeukemia, Myeloid, AcuteMaleMiddle AgedMyelodysplastic SyndromesPrognosisThalidomideTreatment OutcomeLenalidomideThalidomide

Identifiers

PMID28034993
PMCPMC5395113
OpenAlexW2561988418

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.