Evidence map›Paper›PMID 28034966›Full record

ArticleStroke2017

Genetic Predisposition to Ischemic Stroke: A Polygenic Risk Score.

Tsuyoshi Hachiya, Yoichiro Kamatani, Atsushi Takahashi, Jun Hata, Ryohei Furukawa, Yuh Shiwa, Taiki Yamaji, Megumi Hara, Kozo Tanno, Hideki Ohmomo and 31 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 4 pooled it
10.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 84 citations in OpenAlex.

  1. Genetic susceptibility to cerebrovascular disease: A systematic review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018
    Pooled it
  2. Pooled it
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  5. Trial
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  7. Review
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  10. Astrocyte KDM4A mediates chemokines and drives neutrophil infiltration to aggravate cerebral ischemia and reperfusion injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
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  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors at 1 institution in 1 country.

Tsuyoshi HachiyaFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara). thachiya@iwate-med.ac.jp ashimizu@iwate-med.ac.jp.
Yoichiro KamataniFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Atsushi TakahashiFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Jun HataFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Ryohei FurukawaFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Yuh ShiwaFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Taiki YamajiFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Megumi HaraFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Kozo TannoFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Hideki OhmomoFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Kanako OnoFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Naoyuki TakashimaFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Koichi MatsudaFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Kenji WakaiFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Norie SawadaFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Motoki IwasakiFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Kazumasa YamagishiFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Tetsuro AgoFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Toshiharu NinomiyaFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Akimune FukushimaFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Atsushi HozawaFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Naoko MinegishiFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Mamoru SatohFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Ryujin EndoFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Makoto SasakiFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Kiyomi SakataFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Seiichiro KobayashiFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Kuniaki OgasawaraFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Motoyuki NakamuraFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Jiro HitomiFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Yoshikuni KitaFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Keitaro TanakaFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Hiroyasu IsoFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Takanari KitazonoFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Michiaki KuboFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Hideo TanakaFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Shoichiro TsuganeFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Yutaka KiyoharaFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Masayuki YamamotoFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Kenji SobueFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara).
Atsushi ShimizuFrom the Division of Biomedical Information Analysis (T.H., R.F., Y.S., H.O., K. Ono, M. Satoh, A.S.), Division of Biobank and Data Management (T.H., Y.S., M. Satoh), Division of Clinical Research and Epidemiology (K. Tanno, K. Sakata), Division of Innovation and Education (A.F.), Division of Community Medical Supports and Health Record Informatics (M. Satoh), and Division of Public Relations and Planning (R.E.), Iwate Tohoku Medical Megabank Organization (M. Sasaki, S.K., K. Ogasawara, M.N., J. Hitomi, K. Sobue), Iwate Medical University, Japan; Laboratory for Statistical Analysis (Y. Kamatani, A.T.), RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan (M.K.); Laboratory for Omics Informatics, Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan (A.T.); Department of Environmental Medicine (J. Hata), Department of Medicine and Clinical Science (J. Hata, T.A., T.K.), and Center for Cohort Studies (J. Hata, T.N., T.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan (T.Y., N.S., M.I., S.T.); Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan (M.H., K. Tanaka); Department of Public Health, Shiga University of Medical Science, Japan (N.T., Y. Kita); Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan (K.M.); Department of Preventive Medicine (K.W.) and Department of Epidemiology (H.T.), Nagoya University Graduate School of Medicine, Japan; Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan (K.Y.); Department of Preventive Medicine and Epidemiology (A.H.), Department of Biobank (N.M.), and Department of Integrative Genomics (M.Y.), Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Faculty of Nursing Science, Tsuruga Nursing University, Fukui, Japan (Y. Kita); Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Japan (H.I.); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan (H.T.); and Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan (Y. Kiyohara). thachiya@iwate-med.ac.jp ashimizu@iwate-med.ac.jp.
Health Information Management · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThe prediction of genetic predispositions to ischemic stroke (IS) may allow the identification of individuals at elevated risk and thereby prevent IS in clinical practice. Previously developed weighted multilocus genetic risk scores showed limited predictive ability for IS. Here, we investigated the predictive ability of a newer method, polygenic risk score (polyGRS), based on the idea that a few strong signals, as well as several weaker signals, can be collectively informative to determine IS risk.

methodsWe genotyped 13 214 Japanese individuals with IS and 26 470 controls (derivation samples) and generated both multilocus genetic risk scores and polyGRS, using the same derivation data set. The predictive abilities of each scoring system were then assessed using 2 independent sets of Japanese samples (KyushuU and JPJM data sets).

resultsIn both validation data sets, polyGRS was shown to be significantly associated with IS, but weighted multilocus genetic risk scores was not. Comparing the highest with the lowest polyGRS quintile, the odds ratios for IS were 1.75 (95% confidence interval, 1.33-2.31) and 1.99 (95% confidence interval, 1.19-3.33) in the KyushuU and JPJM samples, respectively. Using the KyushuU samples, the addition of polyGRS to a nongenetic risk model resulted in a significant improvement of the predictive ability (net reclassification improvement=0.151; P<0.001).

conclusionsThe polyGRS was shown to be superior to weighted multilocus genetic risk scores as an IS prediction model. Thus, together with the nongenetic risk factors, polyGRS will provide valuable information for individual risk assessment and management of modifiable risk factors.

Indexed as

AgedAged, 80 and overBrain IschemiaCase-Control StudiesFemaleGenetic Predisposition to DiseaseHumansJapanMaleMiddle AgedMultifactorial InheritanceProspective StudiesRisk FactorsStrokegenome-wide association studygenotyperisk assessmentstroke

Identifiers

PMID28034966
PMCPMC5266416
OpenAlexW2563021430

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