ArticlePlant physiology2017
A Flowering Locus C Homolog Is a Vernalization-Regulated Repressor in Brachypodium and Is Cold Regulated in Wheat.
Article in Plant physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 89 citations in OpenAlex.
- Whole genome resequencing analysis of tobacco K326 and its cold sensitive mutant M18.Frontiers in plant science · 2026Article
- Population-scale gene expression analysis reveals the contribution of expression diversity to the modern wheat improvement.Nature communications · 2025Article
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- Historic rewiring of grass flowering time pathways and implications for crop improvement under climate change.The New phytologist · 2025Review
- Targets and mechanisms of epigenetic regulation in the temperate cereal vernalisation process.Frontiers in plant science · 2025Review
- Transcription factor VRT2 reinitiates vernalization when interrupted by warm temperatures in a temperate grass model.Plant physiology · 2024Article
- Distinct roles of H3K27me3 and H3K36me3 in vernalization response, maintenance, and resetting in winter wheat.Science China. Life sciences · 2024Article
- Epigenomic identification of vernalization cis-regulatory elements in winter wheat.Genome biology · 2024Article
- Polygenic architecture of flowering time and its relationship with local environments in the grass Brachypodium distachyon.Genetics · 2024Article
- PeNAC67-PeKAN2-PeSCL23 and B-class MADS-box transcription factors synergistically regulate the specialization process from petal to lip in Phalaenopsis equestris.Molecular horticulture · 2024Article
- The TaSOC1-TaVRN1 module integrates photoperiod and vernalization signals to regulate wheat flowering.Plant biotechnology journal · 2024Article
- Integrated transcriptome and proteome analysis provides insights into CpFPA1 for floral induction in Chimonanthus praecox (Magnoliidae) without FLC in genome.Plant cell reports · 2024Article
- Molecular Evaluation of the Effects ofGenes · 2024Article
- Article
- Evolutionary Dynamics ofPlants (Basel, Switzerland) · 2023Article
- Molecular Links between Flowering and Abiotic Stress Response: A Focus onPlants (Basel, Switzerland) · 2023Review
- Wheat genomic study for genetic improvement of traits in China.Science China. Life sciences · 2022Review
- Flowering time runs hot and cold.Plant physiology · 2022Review
- Genome-Wide Analyses of MADS-Box Genes inPlants (Basel, Switzerland) · 2022Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Winter cereals require prolonged cold to transition from vegetative to reproductive development. This process, referred to as vernalization, has been extensively studied in Arabidopsis (Arabidopsis thaliana). In Arabidopsis, a key flowering repressor called FLOWERING LOCUS C (FLC) quantitatively controls the vernalization requirement. By contrast, in cereals, the vernalization response is mainly regulated by the VERNALIZATION genes, VRN1 and VRN2 Here, we characterize ODDSOC2, a recently identified FLC ortholog in monocots, knowing that it belongs to the FLC lineage. By studying its expression in a diverse set of Brachypodium accessions, we find that it is a good predictor of the vernalization requirement. Analyses of transgenics demonstrated that BdODDSOC2 functions as a vernalization-regulated flowering repressor. In most Brachypodium accessions BdODDSOC2 is down-regulated by cold, and in one of the winter accessions in which this down-regulation was evident, BdODDSOC2 responded to cold before BdVRN1. When stably down-regulated, the mechanism is associated with spreading H3K27me3 modifications at the BdODDSOC2 chromatin. Finally, homoeolog-specific gene expression analyses identify TaAGL33 and its splice variant TaAGL22 as the FLC orthologs in wheat (Triticum aestivum) behaving most similar to Brachypodium ODDSOC2 Overall, our study suggests that ODDSOC2 is not only phylogenetically related to FLC in eudicots but also functions as a flowering repressor in the vernalization pathway of Brachypodium and likely other temperate grasses. These insights could prove useful in breeding efforts to refine the vernalization requirement of temperate cereals and adapt varieties to changing climates.
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