Evidence map›Paper›PMID 28034913›Full record

ArticleJournal of leukocyte biology2017

IL-10 distinguishes a unique population of activated, effector-like CD8

Julia E Rood, Scott W Canna, Lehn K Weaver, John W Tobias, Edward M Behrens

Open access · greenAbstract read
In one paragraph

Article in Journal of leukocyte biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Murine Models of Secondary Cytokine Storm Syndromes.Advances in experimental medicine and biology · 2024
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Julia E RoodDivision of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Scott W CannaMolecular Immunology and Inflammation Branch, National Institute for Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA; and.
Lehn K WeaverDivision of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
John W TobiasMolecular Profiling Core, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Edward M BehrensDivision of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA; behrens@email.chop.edu.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · USNational Institute of Arthritis and Musculoskeletal and Skin Diseases · US

Funding

T32 Institutional Pediatric ResearchT32HD043021 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI Joseph W. St. Geme · 2002 to 2026
$6.4M
TRAINING PROGRAM/RHEUMATIC DISEASEST32AR007442 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI BEHRENS, EDWARD M, MERKEL, PETER A · 1986 to 2018
$5.8M
The Opposing Roles of IL-10 and IFN-gamma in Macrophage Activation SyndromeR01HL112836 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI BEHRENS, EDWARD M · 2013 to 2017
$2.1M
Mechanisms by which IL-10 limits Toll-like Receptor 9 mediated Macrophage ActivatF32AI098337 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI CANNA, SCOTT WILLIAM · 2012 to 2012
$59k
NHLBI NIH HHS R01 HL112836NIAID NIH HHS F32 AI098337NIAMS NIH HHS T32 AR007442NICHD NIH HHS T32 HD043021
6 · The paper itself

Abstract

Immune-mediated liver injury is a central feature of hyperinflammatory diseases, such as hemophagocytic syndromes, yet the immunologic mechanisms underlying those processes are incompletely understood. In this study, we used the toll-like receptor 9 (TLR9)-mediated model of a hemophagocytic syndrome known as macrophage activation syndrome (MAS) to dissect the predominant immune cell populations infiltrating the liver during inflammation. We identified CD8

Indexed as

Lymphocyte ActivationAcute DiseaseAnimalsAntigensCD8-Positive T-LymphocytesCell DifferentiationFemaleInflammationIntercellular Signaling Peptides and ProteinsInterferon-gammaInterleukin-10LiverLymphohistiocytosis, HemophagocyticMaleMice, Inbred C57BLPhenotypeAntigensIntercellular Signaling Peptides and ProteinsInterferon-gammaInterleukin-10Toll-Like Receptor 9cytokinehemophagocytic syndromehepatitis

Identifiers

PMID28034913
PMCPMC5346180
OpenAlexW2563038447

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.