Evidence map›Paper›PMID 28034498›Full record

ReviewEuropean journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology2017

Genomic sequencing and precision medicine in head and neck cancers.

R C Hoesli, M L Ludwig, N L Michmerhuizen, A J Rosko, M E Spector, J C Brenner, A C Birkeland

Abstract readReview
In one paragraph

Review in European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Window of opportunity trials in head and neck cancer.Journal of cancer metastasis and treatment · 2019
    Article
  5. Whole-Exome Sequencing of Sinonasal Small Cell Carcinoma Arising within a Papillary Schneiderian Carcinoma In Situ.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2018
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

R C HoesliDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
M L LudwigDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
N L MichmerhuizenDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
A J RoskoDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
M E SpectorDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA.
J C BrennerDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA.
A C BirkelandDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA. Electronic address: abirkela@med.umich.edu.

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
CELLULAR AND MOLECULAR BIOLOGY AT MICHIGANT32GM007315 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 1985 to 2021
$12.8M
Dissecting Co-Dependent Pathways in Oral CancersU01DE025184 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BRENNER, JOHN CHADWICK, CAREY, THOMAS E. · 2015 to 2018
$3.7M
Advanced Research Training in OtolaryngologyT32DC005356 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CORFAS, GABRIEL · 2002 to 2021
$3.5M
Molecular Mechanisms of Tumor Behavior and Response to Therapy in HPV-positive Oropharyngeal CancerR01CA194536 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CAREY, THOMAS E. · 2016 to 2021
$2.8M
Investigating the Mechanisms of Resistance to EGFR-Targeted Therapy in Head and Neck Squamous Cell CarcinomaF31CA206341 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUDWIG, MEGAN LOREE · 2017 to 2019
$93k
NCI NIH HHS F31 CA206341NCI NIH HHS P30 CA046592NCI NIH HHS R01 CA194536NIDCD NIH HHS T32 DC005356NIDCR NIH HHS U01 DE025184NIGMS NIH HHS T32 GM007315
6 · The paper itself

Abstract

Head and neck squamous cell carcinoma (HNSCC) remains a common and deadly disease. Historically, surgical and chemoradiation treatments have been met with modest success, and understanding of genetic drivers of HNSCC has been limited. With recent next generation sequencing studies focused on HNSCC, we are beginning to understand the genetic landscape of HNSCCs and are starting to identify and advance targeted options for patients. In this review, we describe current knowledge and recent advances in sequencing studies of HNSCC, discuss current limitations and future directions for further genomic analysis, and highlight the translational advances being undertaken to treat this important disease.

Indexed as

Precision MedicineAntineoplastic AgentsCarcinoma, Squamous CellDNA Mutational AnalysisHead and Neck NeoplasmsHigh-Throughput Nucleotide SequencingHumansMolecular Targeted TherapyTranslational Research, BiomedicalAntineoplastic AgentsGenomicsHead and neck cancerHNSCCPersonalized medicinePrecision medicine

Identifiers

PMID28034498
PMCPMC5393934

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.