Evidence map›Paper›PMID 28033531›Full record

ReviewCurrent opinion in neurobiology2017

Synapse biology in the 'circuit-age'-paths toward molecular connectomics.

Dietmar Schreiner, Jeffrey N Savas, Etienne Herzog, Nils Brose, Joris de Wit

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Dendritic Spine Plasticity: Function and Mechanisms.Frontiers in synaptic neuroscience · 2020
    Article
  10. Article
  11. A Brief History of Simulation Neuroscience.Frontiers in neuroinformatics · 2019
    Review
  12. Review
  13. Frontiers in physiology · 2018
    Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dietmar SchreinerBiozentrum, University of Basel, Klingelbergstraße 50-70, 4056 Basel, Switzerland; Institute of Neuroanatomy and Cell Biology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.
Jeffrey N SavasDepartment of Neurology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA.
Etienne HerzogUniv. Bordeaux, IINS, UMR 5297, F-33000 Bordeaux, France; CNRS, IINS, UMR 5297, F-33000 Bordeaux, France.
Nils BroseDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Hermann-Rein-Straße 3, 37075 Göttingen, Germany.
Joris de WitVIB Center for Brain and Disease Research, Herestraat 49, 3000 Leuven, Belgium; Department of Neurosciences, KU Leuven, Herestraat 49, 3000 Leuven, Belgium. Electronic address: joris.dewit@kuleuven.be.

Funding

Proteome Biology of Noise Induced Hearing LossR00DC013805 · NIDCD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SAVAS, JEFFREY NICHOLAS · 2015 to 2017
$747k
European Research Council 311083NIDCD NIH HHS R00 DC013805
6 · The paper itself

Abstract

The neural connectome is a critical determinant of brain function. Circuits of precisely wired neurons, and the features of transmission at the synapses connecting them, are thought to dictate information processing in the brain. While recent technological advances now allow to define the anatomical and functional neural connectome at unprecedented resolution, the elucidation of the molecular mechanisms that establish the precise patterns of connectivity and the functional characteristics of synapses has remained challenging. Here, we describe the power and limitations of genetic approaches in the analysis of mechanisms that control synaptic connectivity and function, and discuss how recent methodological developments in proteomics might be used to elucidate the molecular synaptic connectome that is at the basis of the neural connectome.

Indexed as

ConnectomeAnimalsBrainHumansNeuronsSynapses

Identifiers

PMID28033531
PMCPMC5316339

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.