Evidence map›Paper›PMID 28033523›Full record

ArticleInternational journal for parasitology. Drugs and drug resistance2017

(S)-5-ethynyl-anabasine, a novel compound, is a more potent agonist than other nicotine alkaloids on the nematode Asu-ACR-16 receptor.

Fudan Zheng, Xiangwei Du, Tsung-Han Chou, Alan P Robertson, Edward W Yu, Brett VanVeller, Richard J Martin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal for parasitology. Drugs and drug resistance, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Fudan ZhengDepartment of Chemistry, College of Liberal Arts and Sciences, Iowa State University, Ames, IA, USA.
Xiangwei DuDepartment of Chemistry, College of Liberal Arts and Sciences, Iowa State University, Ames, IA, USA.
Tsung-Han ChouDepartment of Physics and Astronomy, College of Liberal Arts and Sciences, Iowa State University, Ames, IA, USA.
Alan P RobertsonDepartment of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
Edward W YuDepartment of Physics and Astronomy, College of Liberal Arts and Sciences, Iowa State University, Ames, IA, USA.
Brett VanVellerDepartment of Chemistry, College of Liberal Arts and Sciences, Iowa State University, Ames, IA, USA.
Richard J MartinDepartment of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA. Electronic address: rjmartin@iastate.edu.
Iowa State University · US

Funding

RESISTANCE &MODULATION OF LEVAMISOLE RECEPTOR CHANNELSR01AI047194 · NIAID · IOWA STATE UNIVERSITY · PI MARTIN, RICHARD JOHN · 2001 to 2021
$5.8M
Structure and mechanism of the AbgT-family transportersR01AI114629 · NIAID · IOWA STATE UNIVERSITY · PI YU, EDWARD W · 2015 to 2017
$1.1M
Eating worms: an unusual nicotinic acetylcholine receptor from the nematode pharynx as a potential drug targetR21AI121831 · NIAID · IOWA STATE UNIVERSITY · PI ROBERTSON, ALAN P · 2016 to 2017
$393k
NIAID NIH HHS R01 AI047194NIAID NIH HHS R01 AI114629NIAID NIH HHS R21 AI121831
6 · The paper itself

Abstract

Nematode parasites infect ∼2 billion people world-wide. Infections are treated and prevented by anthelmintic drugs, some of which act on nicotinic acetylcholine receptors (nAChRs). There is an unmet need for novel therapeutic agents because of concerns about the development of resistance. We have selected Asu-ACR-16 from a significant nematode parasite genus, Ascaris suum, as a pharmaceutical target and nicotine as our basic moiety (EC

Indexed as

AnabasineAnimalsAscaris suumDrug DiscoveryLevamisoleNicotinic AgonistsOocytesReceptors, NicotinicXenopus5-ethynylanabasineAnabasineLevamisoleNicotinic AgonistsReceptors, NicotinicAgonist-binding siteAnthelminticAscaris suumAsu-ACR-16Nicotine alkaloidsXenopus expression

Identifiers

PMID28033523
PMCPMC5196235
OpenAlexW2559897601

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.