ArticlePloS one2016
An Adaptation to Low Copper in Candida albicans Involving SOD Enzymes and the Alternative Oxidase.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 38 citations in OpenAlex.
- TheJournal of fungi (Basel, Switzerland) · 2026Article
- Fluorescent TAPY-bodipy dyads as tools for imaging fungal mitochondria by confocal microscopy and flow cytometry.Analytical and bioanalytical chemistry · 2026Article
- Discovery of Bacillamide-Acylhydrazone Hybrids as Novel Fungicide Lead Compounds.Journal of fungi (Basel, Switzerland) · 2026Article
- From Fungicide to Phagosome: A One Health View of Copper-Driven Fungal-Bacterial Interactions.Current clinical microbiology reports · 2026Review
- Leveraging Vulnerabilities in Copper Trafficking for Synergistic Antifungal Activity.ACS chemical biology · 2025Article
- Article
- Streptococcus mutans regulates ubiquitin modification of Candida albicans in the bacterial-fungal interaction.PLoS pathogens · 2025Article
- Multifactor transcriptional control of alternative oxidase induction integrates diverse environmental inputs to enable fungal virulence.Nature communications · 2023Article
- Targeting the alternative oxidase (AOX) for human health and food security, a pharmaceutical and agrochemical target or a rescue mechanism?The Biochemical journal · 2022Review
- Interactions between copper homeostasis and the fungal cell wall affect copper stress resistance.PLoS pathogens · 2022Article
- Copper Metabolism inFrontiers in cell and developmental biology · 2022Article
- Metabolic, structural, and proteomic changes in Candida albicans cells induced by the protein-carbohydrate fraction of Dendrobaena veneta coelomic fluid.Scientific reports · 2021Article
- Ceruloplasmin as a source of Cu for a fungal pathogen.Journal of inorganic biochemistry · 2021Article
- Copper Availability Influences the Transcriptomic Response of Candida albicans to Fluconazole Stress.G3 (Bethesda, Md.) · 2021Article
- Expanded role of the Cu-sensing transcription factor Mac1p in Candida albicans.Molecular microbiology · 2020Article
- The antimicrobial and cytotoxic effects of a copper-loaded zinc oxide phosphate cement.Clinical oral investigations · 2020Article
- From economy to luxury: Copper homeostasis in Chlamydomonas and other algae.Biochimica et biophysica acta. Molecular cell research · 2020Review
- Copper-only superoxide dismutase enzymes and iron starvation stress inThe Journal of biological chemistry · 2020Article
- Metabolic Adaptation ofFrontiers in microbiology · 2020Article
- Protein markers forJournal of extracellular vesicles · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In eukaryotes, the Cu/Zn superoxide dismutase (SOD1) is a major cytosolic cuproprotein with a small fraction residing in the mitochondrial intermembrane space (IMS) to protect against respiratory superoxide. Curiously, the opportunistic human fungal pathogen Candida albicans is predicted to express two cytosolic SODs including Cu/Zn containing SOD1 and manganese containing SOD3. As part of a copper starvation response, C. albicans represses SOD1 and induces the non-copper alternative SOD3. While both SOD1 and SOD3 are predicted to exist in the same cytosolic compartment, their potential role in mitochondrial oxidative stress had yet to be investigated. We show here that under copper replete conditions, a fraction of the Cu/Zn containing SOD1 localizes to the mitochondrial IMS to guard against mitochondrial superoxide. However in copper starved cells, localization of the manganese containing SOD3 is restricted to the cytosol leaving the mitochondrial IMS devoid of SOD. We observe that during copper starvation, an alternative oxidase (AOX) form of respiration is induced that is not coupled to ATP synthesis but maintains mitochondrial superoxide at low levels even in the absence of IMS SOD. Surprisingly, the copper-dependent cytochrome c oxidase (COX) form of respiration remains high with copper starvation. We provide evidence that repression of SOD1 during copper limitation serves to spare copper for COX and maintain COX respiration. Overall, the complex copper starvation response of C. albicans involving SOD1, SOD3 and AOX minimizes mitochondrial oxidative damage whilst maximizing COX respiration essential for fungal pathogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.