ArticlePLoS neglected tropical diseases2016
Genome-Wide Analyses of Individual Strongyloides stercoralis (Nematoda: Rhabditoidea) Provide Insights into Population Structure and Reproductive Life Cycles.
Article in PLoS neglected tropical diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- Hookworm genomic diversity and population structure from accessible sample types: A validated approach to generate genome-wide polymorphism datasets from individual third-stage larvae.bioRxiv : the preprint server for biology · 2026Article
- Taxonomy ofParasitology · 2026Review
- A population genetic analysis of the nematodeProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genomic analysis of Strongyloides stercoralis and Strongyloides fuelleborni in Bangladesh.PLoS neglected tropical diseases · 2024Article
- Design and expression of a chimeric recombinant antigen (SsIR-Ss1a) for the serodiagnosis of human strongyloidiasis: Evaluation of performance, sensitivity, and specificity.PLoS neglected tropical diseases · 2024Article
- Strongyloides stercoralis genotyping in a human population in southwestern Iran.Parasites & vectors · 2024Article
- AdvancingPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Human strongyloidiasis: complexities and pathways forward.Clinical microbiology reviews · 2023Review
- The parasitic nematode Strongyloides ratti exists predominantly as populations of long-lived asexual lineages.Nature communications · 2023Article
- From past to present: opportunities and trends in the molecular detection and diagnosis of Strongyloides stercoralis.Parasites & vectors · 2023Review
- Evaluation of various distance computation methods for construction of haplotype-based phylogenies from large MLST datasets.Molecular phylogenetics and evolution · 2022Article
- Strongyloides stercoralis hyperinfection syndrome mimicking pseudomembranous enteritis, complicated by Escherichia coli bacteremia and Pneumocystis jirovecii pneumonia in a patient after immunosuppressive therapy: a case report.BMC infectious diseases · 2022Article
- Surgical treatment of a patient with live intracranial sparganosis for 17 years.BMC infectious diseases · 2022Article
- Molecular typing ofParasitology · 2022Observational
- Characterizing Repeats in Two Whole-Genome Amplification Methods in the Reniform Nematode Genome.International journal of genomics · 2021Article
- Article
- Genomic studies on Strongyloides stercoralis in northern and western Thailand.Parasites & vectors · 2020Article
- Advances in the Molecular and Cellular Biology ofCurrent tropical medicine reports · 2019Article
- Characterization of a non-sexual population of Strongyloides stercoralis with hybrid 18S rDNA haplotypes in Guangxi, Southern China.PLoS neglected tropical diseases · 2019Article
- The population genetics of parasitic nematodes of wild animals.Parasites & vectors · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The helminth Strongyloides stercoralis, which is transmitted through soil, infects 30-100 million people worldwide. S. stercoralis reproduces sexually outside the host as well as asexually within the host, which causes a life-long infection. To understand the population structure and transmission patterns of this parasite, we re-sequenced the genomes of 33 individual S. stercoralis nematodes collected in Myanmar (prevalent region) and Japan (non-prevalent region). We utilised a method combining whole genome amplification and next-generation sequencing techniques to detect 298,202 variant positions (0.6% of the genome) compared with the reference genome. Phylogenetic analyses of SNP data revealed an unambiguous geographical separation and sub-populations that correlated with the host geographical origin, particularly for the Myanmar samples. The relatively higher heterozygosity in the genomes of the Japanese samples can possibly be explained by the independent evolution of two haplotypes of diploid genomes through asexual reproduction during the auto-infection cycle, suggesting that analysing heterozygosity is useful and necessary to infer infection history and geographical prevalence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.