ArticlePLoS biology2016
Transient Duplication-Dependent Divergence and Horizontal Transfer Underlie the Evolutionary Dynamics of Bacterial Cell-Cell Signaling.
Article in PLoS biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- Structural phylogenetics unravels the evolutionary diversification of communication systems in gram-positive bacteria and their viruses.Nature structural & molecular biology · 2025Article
- Extracellular proteolysis of tandemly duplicated pheromone propeptides affords additional complexity to bacterial quorum sensing.PLoS biology · 2024Article
- The leaderless communication peptide (LCP) class of quorum-sensing peptides is broadly distributed among Firmicutes.Nature communications · 2023Article
- Major distinctions between the two oligopeptide permease systems ofMicrobiology (Reading, England) · 2023Article
- A review on surfactin: molecular regulation of biosynthesis.Archives of microbiology · 2023Review
- Large-Scale Identification of Known and Novel RRNPP Quorum-Sensing Systems by RRNPP_Detector Captures Novel Features of Bacterial, Plasmidic, and Viral Coevolution.Molecular biology and evolution · 2023Article
- Article
- Public communication can facilitate low-risk coordination under surveillance.Scientific reports · 2022Article
- Deletion of Rap-Phr systems in Bacillus subtilis influences in vitro biofilm formation and plant root colonization.MicrobiologyOpen · 2021Article
- Impact of Rap-Phr system abundance on adaptation of Bacillus subtilis.Communications biology · 2021Article
- Peptide-based quorum sensing systems inLife science alliance · 2020Article
- A Bacterial Tower of Babel: Quorum-Sensing Signaling Diversity and Its Evolution.Annual review of microbiology · 2020Review
- Rap-Phr Systems from Plasmids pAW63 and pHT8-1 Act Together To Regulate Sporulation in the Bacillus thuringiensis Serovar kurstaki HD73 Strain.Applied and environmental microbiology · 2020Article
- RRNPP-type quorum sensing affects solvent formation and sporulation inMicrobiology (Reading, England) · 2020Article
- Multiple and Overlapping Functions of Quorum Sensing Proteins for Cell Specialization inJournal of bacteriology · 2020Review
- Ratiometric population sensing by a pump-probe signaling system in Bacillus subtilis.Nature communications · 2020Article
- Rap Protein Paralogs of Bacillus thuringiensis: a Multifunctional and Redundant Regulatory Repertoire for the Control of Collective Functions.Journal of bacteriology · 2020Article
- Diversity of the Rap-Phr quorum-sensing systems in the Bacillus cereus group.Current genetics · 2019Article
- Article
- Social behaviours by Bacillus subtilis: quorum sensing, kin discrimination and beyond.Molecular microbiology · 2018Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evolutionary expansion of signaling pathway families often underlies the evolution of regulatory complexity. Expansion requires the acquisition of a novel homologous pathway and the diversification of pathway specificity. Acquisition can occur either vertically, by duplication, or through horizontal transfer, while divergence of specificity is thought to occur through a promiscuous protein intermediate. The way by which these mechanisms shape the evolution of rapidly diverging signaling families is unclear. Here, we examine this question using the highly diversified Rap-Phr cell-cell signaling system, which has undergone massive expansion in the genus Bacillus. To this end, genomic sequence analysis of >300 Bacilli genomes was combined with experimental analysis of the interaction of Rap receptors with Phr autoinducers and downstream targets. Rap-Phr expansion is shown to have occurred independently in multiple Bacillus lineages, with >80 different putative rap-phr alleles evolving in the Bacillius subtilis group alone. The specificity of many rap-phr alleles and the rapid gain and loss of Rap targets are experimentally demonstrated. Strikingly, both horizontal and vertical processes were shown to participate in this expansion, each with a distinct role. Horizontal gene transfer governs the acquisition of already diverged rap-phr alleles, while intralocus duplication and divergence of the phr gene create the promiscuous intermediate required for the divergence of Rap-Phr specificity. Our results suggest a novel role for transient gene duplication and divergence during evolutionary shifts in specificity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.