ArticleMedicine2016
Nailfold capillary abnormalities are associated with type 2 diabetes progression and correlated with peripheral neuropathy.
Article in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Engineered Extracellular Vesicles for Cancer Stem Cell Theranostics: Recent Advances and Future Perspectives.Stem cell reviews and reports · 2026Review
- Nailfold Capillaroscopy: A Non-Invasive Tool for Early Detection of Microvascular Alterations in Children with Type 1 Diabetes MellitusJournal of clinical research in pediatric endocrinology · 2026Article
- Nailfold capillary abnormalities as indicators of diabetic nephropathy progression: a cross-sectional study in type 2 diabetes.Annals of medicine · 2025Article
- Effects of cardiac rehabilitation on in vivo nailfold microcirculation in patients with cardiovascular disease.Heart and vessels · 2025Article
- Nailfold videocapillaroscopy - a novel method for the assessment of hemodynamic incoherence on the ICU.Critical care (London, England) · 2024Article
- Biomarkers and signaling pathways of diabetic nephropathy and peripheral neuropathy: possible therapeutic intervention of rutin and quercetin.Diabetology international · 2024Review
- The power of light and sound: optoacoustic skin imaging for diabetes progression monitoring.Light, science & applications · 2023Article
- Diabetic microvascular disease in non-classical beds: the hidden impact beyond the retina, the kidney, and the peripheral nerves.Cardiovascular diabetology · 2023Review
- Targeting the epigenome of cancer stem cells in pediatric nervous system tumors.Molecular and cellular biochemistry · 2023Review
- Computerized nailfold video-capillaroscopy in type 2 diabetes: A cross-sectional study on 102 outpatients.Journal of diabetes · 2023Article
- Morphological analysis of the impact of diabetes on gingival capillaries with non-invasive blood flow scope - A preliminary study.Journal of dental sciences · 2023Article
- Microvascular and Endothelial Dysfunction in Prediabetes.Life (Basel, Switzerland) · 2023Review
- A pilot study of nailfold capillaroscopy in hereditary transthyretin amyloidosis.Scientific reports · 2022Article
- Capillaroscopic appearance of nailfold vasculature of diabetic nephropathy patients.Archives of endocrinology and metabolism · 2022Article
- Animal Models of Systemic Sclerosis: Using Nailfold Capillaroscopy as a Potential Tool to Evaluate Microcirculation and Microangiopathy: A Narrative Review.Life (Basel, Switzerland) · 2022Review
- Nail Folds Capillaries Abnormalities Associated With Type 2 Diabetes Mellitus Progression and Correlation With Diabetic Retinopathy.Clinical medicine insights. Endocrinology and diabetes · 2022Article
- Skin microvascular function and renal hemodynamics in overweight patients with type 2 diabetes: A cross-sectional study.Microcirculation (New York, N.Y. : 1994) · 2021Article
- Association of abdominal obesity with crossing capillaries in the finger nailfold in type 2 diabetes mellitus.Diabetology international · 2021Article
- Cutaneous microangiopathy in patients with type 2 diabetes: Impaired vascular endothelial growth factor expression and its correlation with neuropathy, retinopathy and nephropathy.Journal of diabetes investigation · 2019Article
- The Effect of Shear Force on Skin Viability in Patients with Type 2 Diabetes.Journal of diabetes research · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes mellitus (DM) is associated with a state of chronic hyperglycemia with a highly increased risk of vascular complications. The current study aimed to investigate microcirculation abnormalities in patients with type 2 DM and those with pre-DM using nailfold videocapillaroscopy (NVC) and evaluate the possible correlation with microvascular complications.A total of 115 patients with type 2 DM, 41 patients with pre-DM, and 37 healthy subjects without diabetes were enrolled. All subjects underwent NVC to evaluate capillary density, length, morphology, distribution, presence of enlarged loops or hemorrhages, and blood flow. NVC score was used to quantitate the aforementioned characteristics.Patients with type 2 DM showed significantly increased alterations including reduced capillary length (29.6%), irregular distribution (35.7%), and abnormal morphology (59.1%), while the corresponding NVC scores were comparable to those of control subjects. In addition, subjects with pre-DM had a significantly higher NVC score and greater alterations in distribution (26.8%) and morphology (48.8%) than control subjects. NVC score was positively correlated with diabetic peripheral neuropathy (DPN) and the number of microvascular complications.NVC identified a high frequency of microcirculation abnormalities in subjects with pre-DM or type 2 DM compared to those in the control group. NVC score was also capable of detecting microvascular complications in patients with type 2 DM and was correlated with DPN and the number of microvascular complications.
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