SynthesisMedicine2016
Combined adductor canal block with periarticular infiltration versus periarticular infiltration for analgesia after total knee arthroplasty.
Synthesis in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03915522 (Adductor Canal Block in an Enhanced Recovery Program After Total Knee Arthroplasty), which is not on this map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Adductor Canal Block in an Enhanced Recovery Program After Total Knee Arthroplasty
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Adductor canal block combined with local infiltration analgesia versus isolated adductor canal block in reducing pain and opioid consumption after total knee arthroplasty: a systematic review and meta-analysis.The Journal of international medical research · 2020Pooled it
- Dose adductor canal block combined with local infiltration analgesia has a synergistic effect than adductor canal block alone in total knee arthroplasty: a meta-analysis and systematic review.Journal of orthopaedic surgery and research · 2019Pooled it
- Pooled it
- Efficacy of direct adductor canal block in pain control and sparing opioid consumption after total knee arthroplasty: a randomized controlled trial.BMC musculoskeletal disorders · 2025Trial
- Efficacy of adding an interspace block to the posterior knee for perioperative pain in total knee arthroplasty: a randomized controlled trial.Acta orthopaedica · 2022Trial
- Comparative analysis of influence of adductor canal block and multimodal periarticular infiltration versus adductor canal block alone on pain and knee range of movement after total knee arthroplasty: a prospective non-randomised study.Musculoskeletal surgery · 2018Trial
- The effect of adductor canal block on outcomes of total knee arthroplasty: A single centre, historical cohort study.Journal of orthopaedics · 2025Article
- Review
- Adductor Canal Blocks Are Not Associated With Improved Early Postoperative Outcomes in Patients Undergoing Total Knee Arthroplasty.Ochsner journal · 2023Article
- A guide to regional analgesia for Total Knee Arthroplasty.EFORT open reviews · 2021Article
- Comparison of Efficacy of Adductor Canal Block, Local Infiltration Analgesia and Both Combined in Postoperative Pain Management After Total Knee Arthroplasty: A Randomized Controlled Trial.Indian journal of orthopaedics · 2021Article
- Analgesic effectiveness of Local Infiltrative Analgesia alone versus combined single dose adductor canal block with Local Infiltrative Analgesia: A single centre case control study.Journal of clinical orthopaedics and trauma · 2020Article
- Controversial Topics in Total Knee Arthroplasty: A 5-Year Update (Part 1).Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2020Review
- Additive effect of continuous adductor canal block and liposomal bupivacaine periarticular injection in total knee arthroplasty.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2019Article
- Decreasing hospital length of stay and enhancing recovery in Total Knee Arthroplasty.Journal of clinical orthopaedics and traumaArticle
- Efficacy of adductor canal block protocol implementation in a multimodal pain management protocol for total knee arthroplasty.Journal of clinical orthopaedics and traumaArticle
- Retrospective Analysis of Pain Relief in Total Knee Replacement Surgeries.Anesthesia, essays and researchesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBoth adductor canal block (ACB) and periarticular infiltration (PI) have been shown to reduce pain after total knee arthroplasty (TKA) without the motor blockade. However, the efficacy and safety of combined ACB with PI (ACB + PI) as compared to PI alone for analgesia after TKA remains controversial. We therefore performed a meta-analysis to compare the effects of ACB + PI with PI alone on pain controll after TKA.
methodsPubMed, Medline, Embase, Web of Science, and the Cochrane Library were searched to identify studies comparing ACB + PI with PI alone for TKA patients. The primary outcomes included pain score with rest or activity and morphine consumption. Secondary outcomes were distance walked, length of hospital stay, and postoperative complications. Relevant data were analyzed using RevMan v5.3.
resultsThree studies involving 337 patients were included. Combined ACB with PI was associated with longer distances walked than PI alone (MD = 7.27, 95% CI: 0.43-14.12, P = 0.04) on postoperative day 1. The outcomes of pain, morphine consumption, length of hospital stay, and postoperative complications were not statistically different between the 2 groups (P > 0.05).
conclusionOur meta-analysis suggests that combined ACB with PI may achieve earlier ambulation for patients after TKA without a reduction in analgesia when compared to PI alone in the early postoperative period. There were no significant differences in morphine consumption, length of hospital stay, and postoperative complications between the 2 groups. However, owing to the variation of included studies, no firm conclusions can be drawn.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.