Evidence map›Paper›PMID 28033244›Full record

Trial reportMedicine2016

Effect of vitamin D3 on self-perceived fatigue: A double-blind randomized placebo-controlled trial.

Albina Nowak, Lukas Boesch, Erik Andres, Edouard Battegay, Thorsten Hornemann, Christoph Schmid, Heike A Bischoff-Ferrari, Paolo M Suter, Pierre-Alexandre Krayenbuehl

Erratum issued Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT02022475 (Effect of Peroral Vitamin D Versus Placebo on Self-reported Fatigue in Adults With Low 25-hydroxy-vitamin D Levels), which is not on this map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02022475 phase3completednot on this map

Effect of Peroral Vitamin D Versus Placebo on Self-reported Fatigue in Adults With Low 25-hydroxy-vitamin D Levels

TypeinterventionalSponsorUniversity of ZurichRan2013 to 2015Enrolled120ConditionsVitamin D DeficiencyArmsVitamin D, placebo
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 3 countries.

Albina NowakDepartment of Internal Medicine Institute for Clinical Chemistry, University Hospital Zurich and University of Zurich Division of Endocrinology, Diabetology and Clinical Nutrition Department of Geriatrics, University Hospital Zurich, Zurich Department of Internal Medicine, Spital Linth, Uznach, Switzerland.
Lukas Boesch
Erik Andres
Edouard Battegay
Thorsten Hornemann
Christoph Schmid
Heike A Bischoff-Ferrari
Paolo M Suter
Pierre-Alexandre Krayenbuehl
Apple (Israel) · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin D deficiency is frequent and has been associated with fatigue in uncontrolled trials.

methodsThis is the first double-blind placebo-controlled clinical trial to investigate the efficacy of per os vitamin D3 (cholecalciferol) in treating fatigue among otherwise healthy persons with low serum 25-hydroxyvitamin D (25(OH)D) levels. We enrolled 120 individuals (mean age 29 ± 6 years, 53% women) presenting with fatigue and vitamin D deficiency (serum 25(OH)D < 20 μg/L). Participants were randomized to a single oral dose of 100,000 units of vitamin D or placebo. The primary endpoint was intra-individual change in the fatigue assessment scale (FAS) at 4 weeks after treatment.

resultThe mean age of the participants was 29 ± 6 years, 53% were women. Mean FAS decreased significantly more in the vitamin D group (-3.3 ± 5.3; 95% confidence interval [CI] for change -14.1 to 4.1) compared with placebo (-0.8 ± 5.3; 95% CI for change -9.0 to 8.7); (P = 0.01). Amelioration of fatigue was reported more frequently in vitamin D than in placebo group (42 [72%] vs. 31 [50%]; P = 0.01; odds ratio [OR] 2.63, 95% CI for OR 1.23-5.62). Among all participants, improvement in fatigue score correlated with the rise in 25(OH)D level (R = -0.22, P = 0.02).

conclusionVitamin D treatment significantly improved fatigue in otherwise healthy persons with vitamin D deficiency.This study was registered at the www.ClinicalTrials.gov Protocol ID NCT02022475.

Indexed as

Administration, OralAdultCholecalciferolDouble-Blind MethodFatigueFemaleHumansMaleSelf ReportVitamin DVitamin D DeficiencyVitaminsYoung Adult25-hydroxyvitamin DCholecalciferolVitamin DVitamins

Identifiers

PMID28033244
PMCPMC5207540
OpenAlexW2566777710

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.