ArticleASAIO journal (American Society for Artificial Internal Organs : 1992)
LVAD Outflow Graft Angle and Thrombosis Risk.
Article in ASAIO journal (American Society for Artificial Internal Organs : 1992). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Fixing the Valve but Not the Flow: Aortic Regurgitation With Thrombus During Durable LVAD Support.JACC. Case reports · 2026Article
- Managing Aortic Regurgitation and Dynamic Aortic Thrombus in a Patient With Left Ventricular Assist Device.JACC. Case reports · 2026Article
- Incidence and clinical implications of aortic root thrombosis in LVAD patients: A single-center experience.Turk gogus kalp damar cerrahisi dergisi · 2026Article
- Successful bridge with extracorporeal left ventricular assist device in a patient with aortic mechanical valve prosthesis.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Article
- Echocardiographic assessment of a novel blood-guiding accessory for left ventricular assist devices in swine.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- Influence of Aortoiliac Geometry on Non-Occlusive Thrombotic Risk Following Endovascular Repair of Abdominal Aortic Aneurysms.Diagnostics (Basel, Switzerland) · 2025Article
- Understanding embolus transport and source to destination mapping of thromboemboli in hemodynamics driven by left ventricular assist device.Scientific reports · 2025Article
- Optimization of flow rate and orientation of outflow graft at implantation for patients with left ventricular assist device.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
- Influence of LVAD Cannula Outflow Graft Flow Rate and Location on Fluid-Particle Interactions and Thrombi Distribution: A Primary Numerical Study.Journal of cardiovascular translational research · 2024Article
- A Computational Investigation of the Effects of Temporal Synchronization of Left Ventricular Assist Device Speed Modulation with the Cardiac Cycle on Intraventricular Hemodynamics.Annals of biomedical engineering · 2024Article
- Development of idealized human aortic models forFrontiers in cardiovascular medicine · 2024Article
- Enhancing the implantation of mechanical circulatory support devices using computational simulations.Frontiers in bioengineering and biotechnology · 2024Article
- Quantitative Assessment of Aortic Hemodynamics for Varying Left Ventricular Assist Device Outflow Graft Angles and Flow Pulsation.Annals of biomedical engineering · 2023Article
- Modeling the Mechanical Microenvironment of Coiled Cerebral Aneurysms.Journal of biomechanical engineering · 2023Article
- Effect of left ventricular assist device on the hemodynamics of a patient-specific left heart.Medical & biological engineering & computing · 2022Article
- Disturbed flow's impact on cellular changes indicative of vascular aneurysm initiation, expansion, and rupture: A pathological and methodological review.Journal of cellular physiology · 2022Review
- Mathematical and Computational Modeling of Device-Induced Thrombosis.Current opinion in biomedical engineering · 2021Article
- Use of patient-specific computational models for optimization of aortic insufficiency after implantation of left ventricular assist device.The Journal of thoracic and cardiovascular surgery · 2021Article
- Pre-implant left ventricular dimension is not associated with worse outcomes after left ventricular assist device implantation.Journal of thoracic disease · 2021Article
- Commentary: Sometimes there is a simpler route!JTCVS techniques · 2020Article
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Authors and funding
8 authors.
Funding
Abstract
This study quantifies thrombogenic potential (TP) of a wide range of left ventricular assist device (LVAD) outflow graft anastomosis angles through state-of-the-art techniques: 3D imaged-based patient-specific models created via virtual surgery and unsteady computational fluid dynamics with Lagrangian particle tracking. This study aims at clarifying the influence of a single parameter (outflow graft angle) on the thrombogenesis associated with flow patterns in the aortic root after LVAD implantation. This is an important and poorly-understood aspect of LVAD therapy, because several studies have shown strong inter and intrapatient thrombogenic variability and current LVAD implantation strategies do not incorporate outflow graft angle optimization. Accurate platelet-level investigation, enabled by statistical treatment of outliers in Lagrangian particle tracking, demonstrates a strong influence of outflow graft anastomoses angle on thrombogenicity (platelet residence times and activation state characterized by shear stress accumulation) with significantly reduced TP for acutely-angled anastomosed outflow grafts. The methodology presented in this study provides a device-neutral platform for conducting comprehensive thrombogenicity evaluation of LVAD surgical configurations, empowering optimal patient-focused surgical strategies for long-term treatment and care for advanced heart failure patients.
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