ArticleeLife2016
Binocular matching of thalamocortical and intracortical circuits in the mouse visual cortex.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Eye-specific drive and binocular suppression in mouse visual cortex during critical period development.bioRxiv : the preprint server for biology · 2026Article
- Binocular Circuitry as a Model for Understanding Experience-Dependent Circuit Development across the Mammalian Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Cortex-Restricted Deletion of Foxp1 Impairs Visual Responses by Disrupting Geniculocortical Connections in a Mouse Model of Autism.Investigative ophthalmology & visual science · 2026Article
- Article
- A Critical Look at Critical Periods.Annual review of vision science · 2025Review
- The world through infant eyes: Evidence for the early emergence of the cardinal orientation bias.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Astrocyte glypican 5 regulates synapse maturation and stabilization.Cell reports · 2025Article
- Article
- A dendritic mechanism for balancing synaptic flexibility and stability.Cell reports · 2024Article
- Microglia are dispensable for experience-dependent refinement of mouse visual circuitry.Nature neuroscience · 2024Article
- Binocular receptive-field construction in the primary visual cortex.Current biology : CB · 2024Article
- Widespread and Multifaceted Binocular Integration in the Mouse Primary Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Experience dependent plasticity of higher visual cortical areas in the mouse.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Monocular deprivation during the critical period alters neuronal tuning and the composition of visual circuitry.PLoS biology · 2023Article
- Article
- Cortical feedback modulates distinct critical period development in mouse visual thalamus.iScience · 2023Article
- Neural circuits for binocular vision: Ocular dominance, interocular matching, and disparity selectivity.Frontiers in neural circuits · 2023Review
- A binocular synaptic network supports interocular response alignment in visual cortical neurons.Neuron · 2022Article
- A theory of cortical map formation in the visual brain.Nature communications · 2022Article
- The Development of Receptive Field Tuning Properties in Mouse Binocular Primary Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
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Authors and funding
2 authors.
Funding
Abstract
Visual cortical neurons are tuned to similar orientations through the two eyes. The binocularly-matched orientation preference is established during a critical period in early life, but the underlying circuit mechanisms remain unknown. Here, we optogenetically isolated the thalamocortical and intracortical excitatory inputs to individual layer 4 neurons and studied their binocular matching. In adult mice, the thalamic and cortical inputs representing the same eyes are similarly tuned and both are matched binocularly. In mice before the critical period, the thalamic input is already slightly matched, but the weak matching is not manifested due to random connections in the cortex, especially those serving the ipsilateral eye. Binocular matching is thus mediated by orientation-specific changes in intracortical connections and further improvement of thalamic matching. Together, our results suggest that the feed-forward thalamic input may play a key role in initiating and guiding the functional refinement of cortical circuits in critical period development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.