Evidence map›Paper›PMID 28032718›Full record

ArticleAnnals of neurology2017

De novo KCNA2 mutations cause hereditary spastic paraplegia.

Andreea Manole, Roope Männikkö, Michael G Hanna, SYNAPS study group, Dimitri M Kullmann, Henry Houlden

Abstract readLetterComment
PubMed Publisher
In one paragraph

Article in Annals of neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Refining Genotypes and Phenotypes inInternational journal of molecular sciences · 2021
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Andreea ManoleDepartment of Molecular Neuroscience and Neurogenetics Laboratory, UCL Institute of Neurology, London, United Kingdom.
Roope MännikköDepartment of Molecular Neuroscience and Neurogenetics Laboratory, UCL Institute of Neurology, London, United Kingdom.
Michael G HannaMRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, London, United Kingdom.
SYNAPS study group
Dimitri M KullmannDepartment of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, United Kingdom.
Henry HouldenDepartment of Molecular Neuroscience and Neurogenetics Laboratory, UCL Institute of Neurology, London, United Kingdom.
Institute of Ophthalmology · MXMRC Prion Unit · GBUniversity College London · GB

Funding

Medical Research Council G0200373Medical Research Council G0801316Medical Research Council G0802760Medical Research Council G1001253Medical Research Council G108/638Medical Research Council G116/147Medical Research Council MR/J004758/1Medical Research Council MR/K000608/1Medical Research Council MR/L01095X/1Wellcome Trust 104033
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Spastic Paraplegia, HereditaryAtaxiaDatabases, GeneticHumansKv1.2 Potassium ChannelMutationKCNA2 protein, humanKv1.2 Potassium Channel

Identifiers

PMID28032718
OpenAlexW2563220265

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.