ArticleThe Journal of comparative neurology2017
Kölliker-Fuse GABAergic and glutamatergic neurons project to distinct targets.
Article in The Journal of comparative neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 100 citations in OpenAlex.
- Molecular Ontology Predicts Output Connections From the Nucleus of the Solitary Tract.The Journal of comparative neurology · 2026Article
- A projection atlas of excitatory and inhibitory inputs to the preBötzinger complex: substrates for multimodal breathing control.Journal of neurophysiology · 2026Article
- Intersectional expression ofAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- High proportions of respiratory and non-respiratory modulated pre-Bötzinger complex neurons receive monosynaptic inputs from the pontine respiratory group in rabbit.Respiratory physiology & neurobiology · 2026Article
- Kölliker-Fuse/Parabrachial Complex PACAP-Glutamate Pathway to the Extended Amygdala Couples Rapid Autonomic and Delayed Endocrine Responses to Acute Hypotension.International journal of molecular sciences · 2025Article
- Multimodal Breathing Control: Pontomedullary Mechanisms and Current Perspectives.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Serotonin neurons are necessary for tonic sodium intake inhibition.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Neuroanatomical and neurochemical organization of brainstem and forebrain circuits involved in breathing regulation.Journal of neurophysiology · 2025Review
- Leveraging GPT-4o for Automated Extraction of Neural Projections from Scientific Literature.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2025Article
- What Links Sleep and Neuropathic Pain?: A Literature Review on the Neural Circuits for Sleep and Pain Control.Nature and science of sleep · 2025Review
- Lateral parabrachial FoxP2 neurons regulate respiratory responses to hypercapnia.Nature communications · 2024Article
- A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution.Nature communications · 2024Article
- Chronic intermittent hypoxia attenuates noradrenergic innervation of hypoglossal motor nucleus.Respiratory physiology & neurobiology · 2024Article
- Central Autonomic Mechanisms Involved in the Control of Laryngeal Activity and Vocalization.Biology · 2024Review
- Exploring the role of the Kölliker-Fuse nucleus in breathing variability by mathematical modelling.The Journal of physiology · 2024Article
- Inhibitory synaptic transmission is impaired in the Kölliker-Fuse of male, but not female, Rett syndrome mice.Journal of neurophysiology · 2023Article
- A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution.bioRxiv : the preprint server for biology · 2023Article
- Opioid suppression of an excitatory pontomedullary respiratory circuit by convergent mechanisms.eLife · 2023Article
- Review
- Parabrachial tachykinin1-expressing neurons involved in state-dependent breathing control.Nature communications · 2023Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The Kölliker-Fuse nucleus (KF) is known primarily for its respiratory function as the "pneumotaxic center" or "pontine respiratory group." Considered part of the parabrachial (PB) complex, KF contains glutamatergic neurons that project to respiratory-related targets in the medulla and spinal cord (Yokota, Oka, Tsumori, Nakamura, & Yasui, 2007). Here we describe an unexpected population of neurons in the caudal KF and adjacent lateral crescent subnucleus (PBlc), which are γ-aminobutyric acid (GABA)ergic and have an entirely different pattern of projections than glutamatergic KF neurons. First, immunofluorescence, in situ hybridization, and Cre-reporter labeling revealed that many of these GABAergic neurons express FoxP2 in both rats and mice. Next, using Cre-dependent axonal tracing in Vgat-IRES-Cre and Vglut2-IRES-Cre mice, we identified different projection patterns from GABAergic and glutamatergic neurons in this region. GABAergic neurons in KF and PBlc project heavily and almost exclusively to trigeminal sensory nuclei, with minimal projections to cardiorespiratory nuclei in the brainstem, and none to the spinal cord. In contrast, glutamatergic KF neurons project heavily to the autonomic, respiratory, and motor regions of the medulla and spinal cord previously identified as efferent targets mediating KF cardiorespiratory effects. These findings identify a novel, GABAergic subpopulation of KF/PB neurons with a distinct efferent projection pattern targeting the brainstem trigeminal sensory system. Rather than regulating breathing, we propose that these neurons influence vibrissal sensorimotor function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.