ArticleOncotarget2017
Long non-coding RNA RPAIN regulates the invasion and apoptosis of trophoblast cell lines via complement protein C1q.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Regulated Cell Death at the Maternal-Fetal Interface in Preeclampsia: Apoptosis, Necroptosis, Pyroptosis, Ferroptosis, Autophagic Cell Death, and Cuproptosis - A Narrative Review.International journal of general medicine · 2026Review
- Review
- lncRNA DANCR promotes the migration an invasion and of trophoblast cells through microRNA-214-5p in preeclampsia.Bioengineered · 2021Article
- Linc8986 and linc0597 in plasma are novel biomarkers for systemic lupus erythematosus.Experimental and therapeutic medicine · 2021Article
- Non-Coding RNAs in Preeclampsia-Molecular Mechanisms and Diagnostic Potential.International journal of molecular sciences · 2021Review
- Roles of noncoding RNAs in preeclampsia.Reproductive biology and endocrinology : RB&E · 2021Review
- Review
- Recent Advances of MicroRNAs, Long Non-coding RNAs, and Circular RNAs in Preeclampsia.Frontiers in physiology · 2021Review
- H3K4me3-Mediated Upregulation of LncRNA-HEIPP in Preeclampsia Placenta Affects Invasion of Trophoblast Cells.Frontiers in genetics · 2020Article
- The Role of Epigenetics in Placental Development and the Etiology of Preeclampsia.International journal of molecular sciences · 2019Review
- [In vitro fertilization-embryo transfer affects focal adhension kinase signaling pathway in early placenta].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2019Article
- LncRNA CRNDE regulates trophoblast cell proliferation, invasion, and migration via modulating miR-1277.American journal of translational research · 2019Article
- Long Noncoding RNA in Preeclampsia: Transcriptional Noise or Innovative Indicators?BioMed research international · 2019Review
- Preeclampsia-Associated Alteration of DNA Methylation in Fetal Endothelial Progenitor Cells.Frontiers in cell and developmental biology · 2019Article
- HIF-1α contributes to tube malformation of human lymphatic endothelial cells by upregulating VEGFR-3.International journal of oncology · 2019Article
- The enhancer RNA lnc-SLC4A1-1 epigenetically regulates unexplained recurrent pregnancy loss (URPL) by activating CXCL8 and NF-kB pathway.EBioMedicine · 2018Article
- Downregulated lncRNA HOXA11-AS Affects Trophoblast Cell Proliferation and Migration by Regulating RND3 and HOXA7 Expression in PE.Molecular therapy. Nucleic acids · 2018Article
- Decreased expression of JHDMID in placenta is associated with preeclampsia through HLA-G.Journal of human hypertension · 2018Article
- Mechanistic Insight into Long Noncoding RNAs and the Placenta.International journal of molecular sciences · 2017Review
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long non-coding RNAs (lncRNAs) are key regulatory molecules that are involved in a variety of biological processes and human diseases. Their impact on early onset preeclampsia remains unclear. In this study, we tested the expression of RPAIN (transcript variant 12 of RPA interacting protein, a non-coding RNA, NR_027683.1) in placenta tissues derived from 25 pregnant women with PE and 15 healthy pregnant women using quantitative real-time PCR. The effect of RPAIN on trophoblast proliferation, invasion, and apoptosis and the underlying mechanisms were examined in trophoblast cell lines (HTR-8/SVneo). The results showed that RPAIN expression levels were significantly increased in early onset preeclamptic placentas compared to normal controls. The proliferation and invasive abilities of the trophoblast cells were significantly inhibited, and the apoptosis abilities of the trophoblast cells were significantly promoted when RPAIN was overexpressed. In addition, the overexpression of RPAIN inhibited the expression of complement protein C1q. Furthermore, C1q overexpression rescued the decreased cell invasion and enhanced cell apoptosis in RPAIN-overexpressing trophoblast cells. Our results suggest that increased RPAIN levels may contribute to the development of preeclampsia through regulating trophoblast invasion and apoptosis via C1q. Therefore, we proposed RPAIN as a novel lncRNA molecule, which might contribute to the development of PE (preeclampsia) and might compose a potential diagnostic and therapeutic target for this disease.
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