Evidence map›Paper›PMID 28032556›Full record

ArticleThe Journal of surgical research2017

Combined reflectance and Raman spectroscopy to assess degree of in vivo angiogenesis after tissue injury.

Shailesh Agarwal, William R Lloyd, Shawn J Loder, Michael T Chung, Charles Hwang, Michael D Morris, Benjamin Levi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of surgical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. The traumatic bone: trauma-induced heterotopic ossification.Translational research : the journal of laboratory and clinical medicine · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Shailesh AgarwalDepartment of Surgery, University of Michigan, Ann Arbor, Michigan.
William R LloydDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan.
Shawn J LoderDepartment of Surgery, University of Michigan, Ann Arbor, Michigan.
Michael T ChungDepartment of Surgery, University of Michigan, Ann Arbor, Michigan.
Charles HwangDepartment of Surgery, University of Michigan, Ann Arbor, Michigan.
Michael D MorrisDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan. Electronic address: mdmorris@umich.edu.
Benjamin LeviDepartment of Surgery, University of Michigan, Ann Arbor, Michigan. Electronic address: blevi@umich.edu.
University of Michigan–Ann Arbor · US

Funding

TRAINING PROGRAM IN ORGANOGENESIST32HD007505 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PASCA DI MAGLIANO, MARINA, SPENCE, JASON · 1997 to 2021
$6.9M
Dynamic Spectroscopic Imaging in Bone BiomechanicsR01AR052010 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORRIS, MICHAEL DAVID · 2005 to 2015
$3.7M
Novel Pathway and Prevention Strategy for Heterotopic OssificationK08GM109105 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEVI, BENJAMIN · 2014 to 2017
$785k
Targeting Inflammation and BMP Signaling in Osteoprogenitor Cells of Heterotopic OssificationF32AR066499 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AGARWAL, SHAILESH · 2015 to 2015
$54k
Howard Hughes Medical InstituteNIAMS NIH HHS F32 AR066499NIAMS NIH HHS L30 AR066947NIAMS NIH HHS R01 AR052010NICHD NIH HHS T32 HD007505NIGMS NIH HHS K08 GM109105
6 · The paper itself

Abstract

backgroundAngiogenesis, the formation of blood vessels, is a critical aspect of wound healing. Disorders of wound healing are often characterized by lack of angiogenesis, a condition frequently observed in aging and diabetic patients. Current techniques for assessing blood at injury sites are limited to contrast-imaging, including angiography. However, these techniques do not directly observe oxygenation of blood and are not amenable to serial evaluation. A multimodal noninvasive reflectance and Raman spectrometer have been proposed to help clinicians as a point-of-care tool to interrogate local angiogenesis and tissue architecture, respectively. The spectrometer system is a rapid, noninvasive, and label-free technology well-suited for the clinical environment. MATERIALS AND

methodsTo demonstrate feasibility, the spectrometer system was used to interrogate angiogenesis serially over 9 wk as a result of heterotopic ossification (HO) development in a validated murine model. End-stage HO was confirmed by micro-computed tomography.

resultsOur preliminary results suggest that reflectance spectroscopy can be used to delineate vessel formation and that pathologic wounds may be characterized by unique spectra. In our model, HO formed at sites 1-3, whereas sites 4 and 5 did not have radiographic evidence of HO.

conclusionsA point-of-care system like that demonstrated here shows potential as a noninvasive tool to assess local angiogenesis and tissue architecture that may allow for timely intervention in a clinical setting.

Indexed as

Neovascularization, PhysiologicWound HealingAnimalsBlood VesselsMiceSpectrum Analysis, RamanX-Ray MicrotomographyAngiogenesisLight scatterNear-infrared lightRaman spectroscopyReflectance spectroscopyTissues

Identifiers

PMID28032556
PMCPMC5536340
OpenAlexW2522936484

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.